{"metadata":{"accession":"W2YRM8","id":"W2YRM8_PHYNI","source_organism":{"taxId":"1317064","scientificName":"Phytophthora nicotianae P10297","fullName":"Phytophthora nicotianae P10297"},"name":"Presenilin","description":["Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Requires the other members of the gamma-secretase complex to have a protease activity"],"length":317,"sequence":"MMFSSAMLLGMLGGNMLVIVIAKFEIPIDVFTLLFAMYNFSVVGVLSIFYQKGTPMWLTQTYLVATSVIMAWQLGQFPEWSTWALVIVLAFYDLCAVLTPCGPLKWLVNLVQQEGRPLPGLLYEAEIRRNHSGHTAQPVRENVYYQCESEIPLRLGSPRDVPEGPTSSTHTSLTPRQVQLRARLIEFYSKHNPSAISRVDKILERYHGRETELWHDLYQKYVTDQGEVDETIKLGLGDFVFYSVLVSRAAKYDFSAMIGCLVSVLMGLGGTLFLLGIYQKALPALPISILLAVMMYFWLRVVFVDFASSALNLGVPL","proteome":null,"gene":"F442_14519","go_terms":[{"identifier":"GO:0042500","name":"aspartic endopeptidase activity, intramembrane cleaving","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0016485","name":"protein processing","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"c661181a01b211ed2d1c8b8b5e8a3bdf1b271f93","counters":{"domain_architectures":4227,"entries":7,"isoforms":0,"proteomes":0,"sets":1,"structures":0,"taxa":1,"dbEntries":{"smart":1,"cathgene3d":1,"pfam":1,"panther":1,"interpro":3},"proteome":0,"taxonomy":1,"similar_proteins":4227}}}