{"metadata":{"accession":"W2RRV0","id":"W2RRV0_CYPE1","source_organism":{"taxId":"1220924","scientificName":"Cyphellophora europaea (strain CBS 101466)","fullName":"Cyphellophora europaea (strain CBS 101466)"},"name":"Mediator of RNA polymerase II transcription subunit 8","description":["Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors"],"length":181,"sequence":"MLAHELKENEDVLSRLVVVPNPQFPIHTQYMIAEHLLQTNTPLPVQEWIESGKEYAREAVQEELLSDFDRRKIWYDAPRAALAQARKQKWGADYTLAEVQAGIETIETGLRRKLVEPPLDDDDDEEFEDEEEEGEEEDSESMEVDPITNAGTTTTTADVSASVPPMSLDVMMRFMSMAKDG","proteome":"UP000030752","gene":"MED8","go_terms":[{"identifier":"GO:0003712","name":"transcription coregulator activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006357","name":"regulation of transcription by RNA polymerase II","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016592","name":"mediator complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"106032a54983356680046256572ad7d11fec777c","counters":{"domain_architectures":3077,"entries":2,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"pfam":1,"interpro":1},"proteome":1,"taxonomy":1,"similar_proteins":3077}}}