{"metadata":{"accession":"U3KP75","id":"U3KP75_RABIT","source_organism":{"taxId":"9986","scientificName":"Oryctolagus cuniculus","fullName":"Oryctolagus cuniculus (Rabbit)"},"name":"Glutathione reductase, mitochondrial","description":["Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol"],"length":462,"sequence":"MMCARMQRSLPAGVTAYDYLVIGGGSGGLATAVVESHKLGGTCVSTRSFPGSRPVMWNTAMHSEFMHDHVDYGFQSCEGKFNWRVIKEKRDAYVSRLNTIYQNNLTKSHIDIIHGYAAFTSDPEPTVEVNGNKYTAPHILIATGGVPSRPHESQIPGASLGITSDGFFELEELPRRSVVVGAGYIAVEIAGIFSALGSKTSLMIRHDKVNSCFKFNFPVHSLPNTHLQQFIYQQVKEVKQTSSGLEVCMVTAAPGRKPTFTTIPNVDCLLWAIGRDPNSSGLNLNNVGIKTDDKGHVVVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFECKKDSKLDYDNIPTVVFSHPPIGTVGLTEDEAIYKYGKENVKTYSTSFTPMYHAVTTRKTKCVMKMVCANREEKVVGIHMQGIGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSAEELVTLR","proteome":"UP000001811","gene":"GSR","go_terms":[{"identifier":"GO:0016491","name":"oxidoreductase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0050660","name":"flavin adenine dinucleotide binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0045454","name":"cell redox homeostasis","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004362","name":"glutathione-disulfide reductase (NADPH) activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0050661","name":"NADP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006749","name":"glutathione metabolic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"786e6e0af388e0b289d71a3e92e80414d4c849c2","counters":{"domain_architectures":105347,"entries":19,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"pfam":2,"ssf":2,"panther":1,"pirsf":1,"ncbifam":2,"prints":2,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":105347}}}