{"metadata":{"accession":"Q9X1X0","id":"MRE11_THEMA","source_organism":{"taxId":"243274","scientificName":"Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)","fullName":"Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)"},"name":"DNA double-strand break repair protein Mre11","description":["Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair (PubMed:21458667, PubMed:21937514, PubMed:24316220). The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA (By similarity). Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity (Probable) (PubMed:20122942, PubMed:21458667, PubMed:24316220)"],"length":385,"sequence":"MINLKELKILHTSDWHLGVTSWTSSRPVDRREELKKALDKVVEEAEKREVDLILLTGDLLHSRNNPSVVALHDLLDYLKRMMRTAPVVVLPGNHDWKGLKLFGNFVTSISSDITFVMSFEPVDVEAKRGQKVRILPFPYPDESEALRKNEGDFRFFLESRLNKLYEEALKKEDFAIFMGHFTVEGLAGYAGIEQGREIIINRALIPSVVDYAALGHIHSFREIQKQPLTIYPGSLIRIDFGEEADEKGAVFVELKRGEPPRYERIDASPLPLKTLYYKKIDTSALKSIRDFCRNFPGYVRVVYEEDSGILPDLMGEIDNLVKIERKSRREIEEVLRESPEEFKEELDKLDYFELFKEYLKKREENHEKLLKILDELLDEVKKSEA","proteome":"UP000008183","gene":"mre11","go_terms":[{"identifier":"GO:0016787","name":"hydrolase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004519","name":"endonuclease activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008408","name":"3'-5' exonuclease activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006259","name":"DNA metabolic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"ef5c77ef2f5507aabdab8fcda639d0d1754eb940","counters":{"domain_architectures":5,"entries":17,"isoforms":0,"proteomes":1,"sets":2,"structures":14,"taxa":1,"dbEntries":{"cathgene3d":3,"pfam":3,"ssf":1,"cdd":1,"panther":1,"ncbifam":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":5}}}