{"metadata":{"accession":"Q8MZM6","id":"Q8MZM6_ANOGA","source_organism":{"taxId":"7165","scientificName":"Anopheles gambiae","fullName":"Anopheles gambiae (African malaria mosquito)"},"name":"thioredoxin-disulfide reductase (NADPH)","description":["Thioredoxin system is a major player in glutathione metabolism, due to the demonstrated absence of a glutathione reductase. Functionally interacts with the Sod/Cat reactive oxidation species (ROS) defense system and thereby has a role in preadult development and life span. Lack of a glutathione reductase suggests antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms"],"length":502,"sequence":"MAPLNQENYEYDLVVIGGGSGGLACAKQAVQLGAKVAVLDFVKPSPRGTKWGLGGTCVNVGCIPKKLMHQASLLGEAIHDSQPYGWQLPDPAAIRHDWATLTESVQNHIKSVNWVTRVDLRDQKVEYVNGLGYFKDDHTVVAVMKNQTERELRAKHVVIAVGGRPRYPDIPGAAEYGITSDDIFSLPQAPGRTLLVGAGYIGLECAGFLKGLGYDVSVMVRSILLRGFDQQMATMVGDSMVEKGIRFHHRSRPLAVEKQPDGRLLVRYETVDEAGTATNGEDVFDTVLFAIGRQAETGTLKLANAGVVTAEGGKSDKLEVDETDHRTNVPHIYAVGDVLYRKPELTPVAIHAGRIIARRLFGGSEERMDYADVATTVFTPLEYGCVGLSEEAAEAAHGKDGIEVYHAYYKPTEFFVPQRSVRYCYLKAVALREGNQRVLGLHFLGPAAGEVIQGFAAALKCGLTMQVLRNTVGIHPTVAEEFTRLAITKRSGLDPTPATCCS","proteome":"UP000007062","gene":"trxR","go_terms":[{"identifier":"GO:0016491","name":"oxidoreductase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0050660","name":"flavin adenine dinucleotide binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0045454","name":"cell redox homeostasis","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004791","name":"thioredoxin-disulfide reductase (NADPH) activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016668","name":"oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":2,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"786e6e0af388e0b289d71a3e92e80414d4c849c2","counters":{"domain_architectures":105347,"entries":20,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":2,"pfam":2,"cathgene3d":2,"pirsf":1,"panther":1,"ncbifam":1,"prints":2,"prosite":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":105347}}}