{"metadata":{"accession":"Q8AVG2","id":"Q8AVG2_XENLA","source_organism":{"taxId":"8355","scientificName":"Xenopus laevis","fullName":"Xenopus laevis (African clawed frog)"},"name":"Protein phosphatase 1A","description":["Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB"],"length":383,"sequence":"MGAFLDKPKMEKHNAHGQGNELRYGLSSMQGWRVEMEDAHTAAIGLPNGLDAWSFFAVYDGHAGSQVAKYCCEHLLDHITSNQDFKGTDGHLSVWSVKNGIRTGFLQIDEHMRVISEKKHGADRSGSTAVGVMLSPNHIYFINCGDSRGLLCRSKKVHFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVYEIERSEEDDQFIILACDGIWDVMGNEELCDFVGSRLEVTDDLERVCNEIVDTCLYKGSRDNMSVILICFPSAPKVLPEAVKREAELDKYLEGRVEDIIKKQGEEGVPDLVHVMRTLASENIPHLPPGGELASKRSVIEAVYNRLNPYRNDDTDSASTDDMW","proteome":"UP000186698","gene":"ppm1a.S","go_terms":[{"identifier":"GO:0000287","name":"magnesium ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004721","name":"phosphoprotein phosphatase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0030145","name":"manganese ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004722","name":"protein serine/threonine phosphatase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006470","name":"protein dephosphorylation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0043169","name":"cation binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":2,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"6f03d9f1aa22bd168030dc5029ba03af33e54c17","counters":{"domain_architectures":4224,"entries":17,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"smart":1,"profile":1,"cdd":1,"pfam":2,"panther":1,"prosite":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":4224}}}