{"metadata":{"accession":"Q84Y01","id":"ITPK1_MAIZE","source_organism":{"taxId":"4577","scientificName":"Zea mays","fullName":"Zea mays (Maize)"},"name":"Inositol-tetrakisphosphate 1-kinase 1","description":["Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3 and participates in phytic acid biosynthesis in developing seeds (PubMed:12586875, PubMed:32123645). Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not (PubMed:12586875). Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway (PubMed:12586875). Also able to phosphorylate Ins(3,5,6)P3 but not Ins(1,4,5)P3, Ins(2,4,5)P3, Ins(1,3,4,6)P4 nor Ins(1,3,5,6)P4. Has higher specific activity on Ins(3,4,5,6)P4 than Ins(1,3,4)P3 and Ins(3,5,6)P3 (PubMed:12586875). Can also could use Ins(1,2,5,6)P4 as a substrate (PubMed:12586875). Able to add a beta-phosphate to the 3 positions of Ins(1,2,3,4,5)P5 and to add beta-phosphate to InsP6 to yield 5-InsP7, thus exhibiting InsP6 kinase activity (PubMed:35635723). Also has Ins(1,3,4,5,6)P5 phosphatase activity (PubMed:35635723)"],"length":342,"sequence":"MASDAAAEPSSGVTHPPRYVIGYALAPKKQQSFIQPSLVAQAASRGMDLVPVDASQPLAEQGPFHLLIHKLYGDDWRAQLVAFAARHPAVPIVDPPHAIDRLHNRISMLQVVSELDHAADQDSTFGIPSQVVVYDAAALADFGLLAALRFPLIAKPLVADGTAKSHKMSLVYHREGLGKLRPPLVLQEFVNHGGVIFKVYVVGGHVTCVKRRSLPDVSPEDDASAQGSVSFSQVSNLPTERTAEEYYGEKSLEDAVVPPAAFINQIAGGLRRALGLQLFNFDMIRDVRAGDRYLVIDINYFPGYAKMPGYETVLTDFFWEMVHKDGVGNQQEEKGANHVVVK","proteome":"UP000007305","gene":"ITPK1","go_terms":[{"identifier":"GO:0000287","name":"magnesium ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0047325","name":"inositol-3,4,5,6-tetrakisphosphate 1-kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0052725","name":"inositol-1,3,4-trisphosphate 6-kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0052726","name":"inositol-1,3,4-trisphosphate 5-kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0032957","name":"inositol trisphosphate metabolic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"4698f712b3c343efaf6f66851705ac985cb8c2ed","counters":{"domain_architectures":4246,"entries":9,"isoforms":0,"proteomes":1,"sets":2,"structures":5,"taxa":1,"dbEntries":{"pfam":2,"cathgene3d":1,"ssf":1,"pirsf":1,"panther":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":4246}}}