{"metadata":{"accession":"Q7YS81","id":"MYOG_BOVIN","source_organism":{"taxId":"9913","scientificName":"Bos taurus","fullName":"Bos taurus (Bovine)"},"name":"Myogenin","description":["Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Also cooperates with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Also plays a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts (By similarity)"],"length":224,"sequence":"MELYETSPYFYQEPHFYDGENYLPVHLQGFEPPGYERAELSLSPEARVPLEDKGLGPAEHCPGQCLPWACKVCKRKSVSVDRRRAATLREKRRLKKVNEAFEALKRSTLLNPNQRLPKVEILRSAIQYIERLQALLSSLNQEERDLRYRGGGGPQAAVPSECSSHSASCSPQWGSALEFGPNPGDHLLPADPTDAHNLHSLTSIVDSITVEDVAAAFPDETIPN","proteome":"UP000009136","gene":"MYOG","go_terms":[{"identifier":"GO:0046983","name":"protein dimerization activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006355","name":"regulation of DNA-templated transcription","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0007517","name":"muscle organ development","category":{"code":"P","name":"biological_process"}}],"protein_evidence":2,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"650c48b51bd75430ad96dc184cba63fb6ade769a","counters":{"domain_architectures":2089,"entries":13,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"smart":2,"cathgene3d":1,"profile":1,"cdd":1,"ssf":1,"pfam":2,"panther":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":2089}}}