{"metadata":{"accession":"Q7SYH5","id":"SC5A8_XENLA","source_organism":{"taxId":"8355","scientificName":"Xenopus laevis","fullName":"Xenopus laevis (African clawed frog)"},"name":"Sodium-coupled monocarboxylate transporter 1","description":["Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1 (By similarity). Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane (By similarity). Mediates sodium-coupled electrogenic transport of pyroglutamate (5-oxo-L-proline) (By similarity). Can mediate the transport of chloride, bromide, iodide and nitrate ions when external concentration of sodium ions is reduced (By similarity)"],"length":622,"sequence":"MVTPGNIGSFTVWDYLVFALMLLISAVIGIYYAFAGGGQKTSKDFLMGGRSMTAVPVALSLTASFMSAVTVLGTPAEVYRFGAMFIIFAFSYTIVVIISSEVFLPVFYRLGITSTYEYLELRFNKFVRLLGTILFIIQTVLYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTMGGLKAVVWTDVFQVGIMVAGFTSVIIRAVVVQGGIGPILNDSYYGDRLNFWDFDPNPLKRHTFWTIVVGGTFTWTGIYGVNQAQVQRYIACKTRFQAKMSLYVNLIGLWAILACAVLSGLAMYSIYKDCDPWTAKFVSAPDQLMPYLALDILRDYPGLPGLFVSCAYSGTLSTVSSSINALAAVTVEDLIKPYIRSLSEKKMSWISKGTSLLYGAICIGMAGIASLMGGLLQAALSIFGMVGGPLLGLFSLGILFPFVNSLGAVIGLLSGFAISLWVGIGSQIYAPSPSSSLPKPLSLEGCNFTSIESNWTSTVMPMMTTLIPETQVSSRPELADSWYSLSYLYFSTIGTIVAVLVGVIVSLLSGGLKQNVNREFLLTSEDFSYLNVLFSPCKEKGQEEKVEVLNWKARRTDNDMEQGTDNPAFNNMEMTSTEKGEKTNGITA","proteome":"UP000186698","gene":"slc5a8","go_terms":[{"identifier":"GO:0022857","name":"transmembrane transporter activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0055085","name":"transmembrane transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":2,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"2b2a6841043927bd4b57fafc3151ff36fdcbb775","counters":{"domain_architectures":98886,"entries":10,"isoforms":2,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cdd":1,"profile":1,"cathgene3d":1,"panther":1,"ncbifam":1,"pfam":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":98886}}}