{"metadata":{"accession":"Q7QJE5","id":"Q7QJE5_ANOGA","source_organism":{"taxId":"7165","scientificName":"Anopheles gambiae","fullName":"Anopheles gambiae (African malaria mosquito)"},"name":"non-specific serine/threonine protein kinase","description":["Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP. Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation"],"length":242,"sequence":"MAVAVEKQEPVQQLLKQGAEGKLYIGTYKGNRCLVKERFEKKYRHPALDRQLTRQRIKAEQKAFQRCAAAGLSTPALYGVDLEQRKIYMEYLERSRTAKEFIDELTATTAADALQESAQLKQLAEQIGHMVGVLHRNNLVHGDLTTSNMLLDPVEKGAEESVFPYRLVTIDFGLSHFSDNHENKGVDLYVLERAILSAHSQLPGLFGMILEAYREHNTNHCKETIAKYEEVRARGRKRTMVG","proteome":"UP000007062","gene":"1269747","go_terms":[{"identifier":"GO:0004672","name":"protein kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006468","name":"protein phosphorylation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004674","name":"protein serine/threonine kinase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"726173b0dde7bbc50c5d845a39c992d18faf18f3","counters":{"domain_architectures":887312,"entries":12,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"profile":1,"ssf":1,"pfam":1,"cathgene3d":2,"panther":1,"ncbifam":1,"prosite":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":887312}}}