{"metadata":{"accession":"Q708D0","id":"Q708D0_NARAN","source_organism":{"taxId":"174156","scientificName":"Narceus annularis","fullName":"Narceus annularis (Millipede)"},"name":"Hedgehog protein","description":["The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product. Once cleaved, the C-product has no signaling activity and diffuses from the cell","[Protein hedgehog N-product]: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development","[Protein hedgehog]: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product"],"length":511,"sequence":"ERPPGQVSKLDPLEYGTRCSEEKLKENKKKKKKKQKAKEHGESRSELGIRIYGEDDRRWPGAVAKLCRAGGGGGGGGEVDILHMYSSVTMAKQEVLLAVVLLVLVLSEAVLCCGPGRSAGRRRRPRKLTPLVFKQHVPNVSENTLGASGLPEGRITRDDSRFKELVPNYNTDIYFKDEEGTGADRLMTQRCKEKLNTLAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESRSHIHCSVKSESSPAAKSGGCFHGNSTVMTRRGGAKLMSQVSIGDELLALSSDGSPVFSEVLLFLDRQPSSRRLFRVIETEGGHSVTLTPTHLIYVAVGPGEQSEARYAEDVRPGHRVFVVEDGHEGLGQKKVSLRRVVRVTTREEDGGAFAPLTHQGNVIVNGVVTSCYAVVDDQSLAHWAFAPYRFVHYVRSTWPTMPKWLLRWWWSAEESSTSDSWQQNGVHWYASALYHISQFILPHRLRA","proteome":null,"gene":"hh","go_terms":[{"identifier":"GO:0007267","name":"cell-cell signaling","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016540","name":"protein autoprocessing","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016539","name":"intein-mediated protein splicing","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0007275","name":"multicellular organism development","category":{"code":"P","name":"biological_process"}}],"protein_evidence":2,"source_database":"unreviewed","is_fragment":true,"in_alphafold":true,"in_bfvd":false,"ida_accession":"a73b552ecc23d61627e97e1396c48fbde1a4af23","counters":{"domain_architectures":2934,"entries":21,"isoforms":0,"proteomes":0,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"pfam":2,"ssf":2,"smart":2,"profile":1,"cdd":1,"panther":1,"prints":1,"interpro":9},"proteome":0,"taxonomy":1,"similar_proteins":2934}}}