{"metadata":{"accession":"Q6DFE8","id":"Q6DFE8_XENLA","source_organism":{"taxId":"8355","scientificName":"Xenopus laevis","fullName":"Xenopus laevis (African clawed frog)"},"name":"Tyrosyl-DNA phosphodiesterase 1","description":["DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate"],"length":597,"sequence":"MDRTSASQQSNYGKWTLSSSEDEAEDSTIPSTPSSSRQSLDSVPHYTCSDARKASHKRKVNPVKFEEMSKQESIPAKKIKTESEVSGWCLSSSDEESKPTQSEQKKKIKTDTIDAPVRAQNIQGHTEVTQVKYKTPSDSQDIWDLLQAGEPFRFYLTKVTGIKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDIEWLVKQYPEEFRNKPLLIVHGEKRESKTKLHEDAHPYEHIRLCQAKLDIAYGTHHTKMMLLLYTEGLRVVIHTSNLIREDWYQKTQGIWLSPLYPRLPEGASVSAGESSTNFRSDLIAYLASYNSPSLREWMDIIKQHDLSETRVYLIGSTPGRFQGKDKDKWGHFRLRKLLRENTSAGPDKEMWPVIGQFSSIGSMGVDKTKWLCSEFTESLKTLGKSIKSLQKSEIPLRLIYPSVDNVRTSLEGYPAGGSLPYSIQTAQKQPWLHSYFHKWKAETSGRSQAIPHIKTYMRFSPDFQNLAWFLVTSANLSKAAWGSLEKNGAQLFIRSYELGVLFLPSAFDTNTFNVKVNIYSHNEPSGNAFPVPYDLPPEHYGSKDRPWVWNIPYVNAPDTHGNIWCPP","proteome":"UP000186698","gene":"tdp1.L","go_terms":[{"identifier":"GO:0008081","name":"phosphoric diester hydrolase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006281","name":"DNA repair","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005634","name":"nucleus","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":2,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"6047af90a04d599ec7aba9e7c46b223aea6dd18c","counters":{"domain_architectures":4974,"entries":7,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":1,"cdd":2,"panther":1,"pfam":1,"interpro":1},"proteome":1,"taxonomy":1,"similar_proteins":4974}}}