{"metadata":{"accession":"Q60648","id":"SAP3_MOUSE","source_organism":{"taxId":"10090","scientificName":"Mus musculus","fullName":"Mus musculus (Mouse)"},"name":"Ganglioside GM2 activator","description":["Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity. Has cholesterol transfer activity (By similarity)"],"length":193,"sequence":"MHRLPLLLLLGLLLAGSVAPARLVPKRLSQLGGFSWDNCDEGKDPAVIKSLTIQPDPIVVPGDVVVSLEGKTSVPLTAPQKVELTVEKEVAGFWVKIPCVEQLGSCSYENICDLIDEYIPPGESCPEPLHTYGLPCHCPFKEGTYSLPTSNFTVPDLELPSWLSTGNYRIQSILSSGGKRLGCIKIAASLKGR","proteome":"UP000000589","gene":"Gm2a","go_terms":[{"identifier":"GO:0008047","name":"enzyme activator activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006689","name":"ganglioside catabolic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"f987f23ac86eaabd183ac60f083a5628166b7889","counters":{"domain_architectures":12194,"entries":8,"isoforms":0,"proteomes":1,"sets":1,"structures":1,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":1,"pfam":1,"smart":1,"panther":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":12194}}}