{"metadata":{"accession":"Q52KX5","id":"Q52KX5_XENLA","source_organism":{"taxId":"8355","scientificName":"Xenopus laevis","fullName":"Xenopus laevis (African clawed frog)"},"name":"S-adenosylmethionine sensor upstream of mTORC1","description":["S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase"],"length":397,"sequence":"MEPVLPARGNRENVLGKATAEMYVSSFPSEQKTEQEKLSGVVKRVHRDLRKKYREAGDFEKIWLEHCKDKGRLCEYAVAMKALADNHWAKKCEGEGRIEWCLGVCQEYFFNGGKKKAIEKDARRTALNKLQSSNCAEAEVSDFSVPNPKSLNDEYMIGKIRLLDVGSCYNPFLKYEDFLAVGIDIVPAVETVFKCDFLNLQIQRPLQLAPDAIDAFLKQLQSPIDYLPAELFHVVVFSLLLSYFPSPYQRWICCKKAHELLTFNGLLLIITPDSSHQNRHAVIMKSWKIAIESLGFRRMTYSKFSHMHLMAFRKTSLKTTSDLITRNYPDMLYIPQDLNYDREEDHFSNCCLRSELEDEQLACGFTELPDTPYDSDSGDSHNSTMPFYEFEDPILIG","proteome":"UP000186698","gene":"samtor.S","go_terms":null,"protein_evidence":2,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"b4004ad669ddcff91933f785af02ff8b8433ab50","counters":{"domain_architectures":2617,"entries":7,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"panther":1,"hamap":1,"pfam":1,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":2617}}}