{"metadata":{"accession":"Q295U5","id":"INT13_DROPS","source_organism":{"taxId":"46245","scientificName":"Drosophila pseudoobscura pseudoobscura","fullName":"Drosophila pseudoobscura pseudoobscura (Fruit fly)"},"name":"Protein asunder","description":["Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit Polr2A/Rbp1 and Spt5, and (2) degrading the exiting nascent RNA transcript via endonuclease activity. The integrator complex is also involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5"],"length":674,"sequence":"MFERNQKTIFVLDHTRYFSIASEEYISMDFLKGKPSAHSSAGGSSQFSKSLWTCACESSIEYCRVVWDLFPGKKHVRFIVSDTAAHIVNTWSASTQNMSHVMNAMVMVGVPSRSMPQSSDYSVIHGLRAAIEALAEPTDEQSQAMASGVPDDLILNEGRVICITSARDNTSMKSLEDIFNTVLIQQNVLSATPPKKGLGINHCHLVILNIVPLGIDSMVTNRNLLEISPLLDVEIHTVGAPDISYKLTHLILDHYDLASTTVTNIPMKEEQNANSSANYDVEILHSRRAHSITCGPDFSLPTSIKQGATYETVTLKWCTPRGCGSADLQPCLGQFLVTPVDVTSRPSSCLINFLLNGRSVLLEMPRKTGSKATSHMLSARGGEIFIHSLCITRSCMDEAPSIADGPGGRVNDYRTSELGQLMKMSRMVPLKSRDPAAPNLPRRLPRYFPLTTTSTVLFHLQRHLSWLPHFLHLLVKEMDKQDEVRCQQHIHELYKSASRGDVLPFTHTNGARLKPHKAKDQYRLLYRELEQLIQLNASTVHHKNLLESLQTLRAAYGDAPSKSEAGTANLRSFTESPLSPERLEAMSNVSISSSTNSNSLLKASKRRMSNCGTRSLLDIISSAERSQSNKRLDFSGRICTPIGQIAKLYPDFGNKEKDAAAAAAASGVGVAPKE","proteome":"UP000001819","gene":"asun","go_terms":null,"protein_evidence":3,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"1713aee94953013f432608a11e4d07ad69b79d4e","counters":{"domain_architectures":1926,"entries":3,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"panther":1,"pfam":1,"interpro":1},"proteome":1,"taxonomy":1,"similar_proteins":1926}}}