{"metadata":{"accession":"Q08AG7","id":"MZT1_HUMAN","source_organism":{"taxId":"9606","scientificName":"Homo sapiens","fullName":"Homo sapiens (Human)"},"name":"Mitotic-spindle organizing protein 1","description":["Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome (PubMed:20360068, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38609661, PubMed:39321809)"],"length":82,"sequence":"MASSSGAGAAAAAAAANLNAVRETMDVLLEISRILNTGLDMETLSICVRLCEQGINPEALSSVIKELRKATEALKAAENMTS","proteome":"UP000005640","gene":"MZT1","go_terms":[{"identifier":"GO:0033566","name":"gamma-tubulin complex localization","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0000931","name":"gamma-tubulin ring complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"ee14ad8459e354c910fcdd424c3bfbb5f80e7007","counters":{"domain_architectures":3115,"entries":3,"isoforms":0,"proteomes":1,"sets":0,"structures":26,"taxa":1,"dbEntries":{"panther":1,"pfam":1,"interpro":1},"proteome":1,"taxonomy":1,"similar_proteins":3115}}}