{"metadata":{"accession":"P15874","id":"GRPE_BACSU","source_organism":{"taxId":"224308","scientificName":"Bacillus subtilis (strain 168)","fullName":"Bacillus subtilis (strain 168)"},"name":"Protein GrpE","description":["Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding"],"length":187,"sequence":"MSEEKQTVEQNETEEQEIIEEQAAADEQQEETNESELLQNQINELQGLLEEKENKLLRVQADFENYKRRSRLEMEASQKYRSQNIVTDLLPALDSFERALQVEADNEQTKSLLQGMEMVHRQLVEALKKEGVEAIEAVGQEFDPNLHQAVMQAEDENYGSNIVVEEMQKGYKLKDRVIRPSMVKVNQ","proteome":"UP000001570","gene":"grpE","go_terms":[{"identifier":"GO:0000774","name":"adenyl-nucleotide exchange factor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0042803","name":"protein homodimerization activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0051087","name":"protein-folding chaperone binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006457","name":"protein folding","category":{"code":"P","name":"biological_process"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"bcfacd3ac840c2030716357b736a826603778042","counters":{"domain_architectures":36652,"entries":14,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"cdd":1,"ncbifam":1,"panther":1,"hamap":1,"pfam":1,"prosite":1,"prints":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":36652}}}