{"metadata":{"accession":"P0DMM8","id":"SCX1_TITTR","source_organism":{"taxId":"369776","scientificName":"Tityus trivittatus","fullName":"Tityus trivittatus (Argentinean scorpion)"},"name":"Beta-mammal Tt1g","description":["Beta toxins modify sodium channel function in two ways: an excitatory effect (shifting the activation process to more negative potential) and/or a depressant effect (reducing the peak current). At concentration of 500 nM this toxin produces channel opening at more negative potentials in hNav1.2/SCN2A and hNav1.3/SCN3A, which shows the biggest effect. On the other hand the peak current is decreased in hNav1.4/SCN4A and hNav1.5/SCN5A channels, without apparent modification of the activation gate. This toxin is active against mammals"],"length":84,"sequence":"MKGMILFISCILLIGIVVECKEGYLMDHEGCKLSCFIRPSGYCGRECAIKKGSSGYCAWPACYCYGLPNWVKVWERATNRCGKK","proteome":null,"gene":null,"go_terms":[{"identifier":"GO:0006952","name":"defense response","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0008200","name":"ion channel inhibitor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0019871","name":"sodium channel inhibitor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005576","name":"extracellular region","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0090729","name":"toxin activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"91cf9b65efdbf553bdb99b3376bcd79a3f1ef44f","counters":{"domain_architectures":1101,"entries":12,"isoforms":0,"proteomes":0,"sets":1,"structures":0,"taxa":1,"dbEntries":{"smart":1,"pfam":1,"cathgene3d":1,"ssf":1,"profile":1,"cdd":1,"prints":1,"interpro":5},"proteome":0,"taxonomy":1,"similar_proteins":1101}}}