{"metadata":{"accession":"L5KXS5","id":"L5KXS5_PTEAL","source_organism":{"taxId":"9402","scientificName":"Pteropus alecto","fullName":"Pteropus alecto (Black flying fox)"},"name":"Tumor necrosis factor ligand superfamily member 18","description":["Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. Promotes leukocyte adhesion to endothelial cells. Regulates migration of monocytes from the splenic reservoir to sites of inflammation"],"length":180,"sequence":"MSLRHMENLPLHHPSPPGAQRLSWKRWLLYSLIAFLLFLYFSALLFTLLSSKTVNETCVAKFGPSPSKWQMASAKPSCVKKRADWKLEILEKGLYVIYGQVAPNTSYKEPAPFEVRLRKNENIIQTLTDNTKIQNVGGTYELHAGDVIDLIFNSEHQVLENSTYWGILMLATPPLHFLES","proteome":"UP000010552","gene":"PAL_GLEAN10017790","go_terms":[{"identifier":"GO:0005164","name":"tumor necrosis factor receptor binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006955","name":"immune response","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0032813","name":"tumor necrosis factor receptor superfamily binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0002309","name":"T cell proliferation involved in immune response","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0033209","name":"tumor necrosis factor-mediated signaling pathway","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":null,"counters":{"domain_architectures":0,"entries":7,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"profile":1,"cathgene3d":1,"ssf":1,"panther":1,"interpro":3},"proteome":1,"taxonomy":1}}}