{"metadata":{"accession":"K9J061","id":"K9J061_DESRO","source_organism":{"taxId":"9430","scientificName":"Desmodus rotundus","fullName":"Desmodus rotundus (Vampire bat)"},"name":"Sorbitol dehydrogenase","description":["Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility"],"length":356,"sequence":"MAATKPENLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWQHGRIGDFVVKKPMVLGHEASGTVVKVGSLVTHLQPGDRVAIEPGAPRETDEFCKIGRYNLSPSIFFCATPPDDGNLCRFYKHNASFCYKLPDNVTFEEGALIEPLSVGIHACRRAGVTLGNKVLVCGAGPIGLVNLLVAKAMGAVQVVVTDLSASRLSKAKEAGADFVLQISKESPQEIASKVEGLLGRKPEVTIECTGAEAAIQAGIYATCPGGTLVLVGLGSEMTNVPLVHAATREVDIKGVFRYCNTWPVAISMLASKSVNVKSLVTHRFPLEKALEAFEASKKGLGLKVMIKCDPNNQDP","proteome":null,"gene":null,"go_terms":[{"identifier":"GO:0016616","name":"oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016491","name":"oxidoreductase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008270","name":"zinc ion binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":2,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"6e6b076d581cf5733167d9dad5b9a31c66e6d8d3","counters":{"domain_architectures":323634,"entries":17,"isoforms":0,"proteomes":0,"sets":3,"structures":0,"taxa":1,"dbEntries":{"ssf":2,"cdd":1,"smart":1,"cathgene3d":2,"pfam":2,"panther":1,"prosite":1,"interpro":7},"proteome":0,"taxonomy":1,"similar_proteins":323634}}}