{"metadata":{"accession":"K4R3N8","id":"K4R3N8_STRDJ","source_organism":{"taxId":"1214101","scientificName":"Streptomyces davaonensis (strain DSM 101723 / JCM 4913 / KCC S-0913 / 768)","fullName":"Streptomyces davaonensis (strain DSM 101723 / JCM 4913 / KCC S-0913 / 768)"},"name":"Serine hydroxymethyltransferase","description":["Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism"],"length":482,"sequence":"MSEQPLSPESTAYRAALDVIRAVEPRVADAIGQEVHDQREMLKLIASENYASPATLLAMGNWFSDKYAEGTIGRRFYAGCRNVDTVESLAAEHAKELFGARHAYVQPHSGIDANLVAFWSVLAARVETPALEKAGVRQVNDLSDADWAELRQAFGNQRMLGMSLDAGGHLTHGFRPNISGKMFDQRSYGTDPVTGLVDYEALRASAREFKPLIIVAGYSAYPRLVNFRIMREIADEVGATLMVDMAHFAGLVAGKVLTGDFEPVPHAQIVTTTTHKSLRGPRGGMVLCDDSLKDQVDRGCPMVLGGPLPHVMAAKAVALAEARRPSFQDYAQRIVDNSRALAEGLMRRGATLVTGGTDNHLNLIDVATSYGLTGRQAEAALLESGIVTNRNAIPADPNGAWYTSGIRIGTPALTTRGLGTAEMDEVAGLIDRVLTTSEPGTTKSGAPSKAAHVLDAKIADEISRRATDLVAGFPLYPEIDLG","proteome":"UP000008043","gene":"glyA5","go_terms":[{"identifier":"GO:0004372","name":"glycine hydroxymethyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0030170","name":"pyridoxal phosphate binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0019264","name":"glycine biosynthetic process from L-serine","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0035999","name":"tetrahydrofolate interconversion","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"69fe7822ce6006f2b53b4f3d0ae9f9940e899c56","counters":{"domain_architectures":1844,"entries":18,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"pfam":1,"cdd":1,"cathgene3d":2,"ncbifam":2,"pirsf":1,"hamap":1,"panther":1,"prosite":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":1844}}}