{"metadata":{"accession":"J4UJF5","id":"SIDD_BEAB2","source_organism":{"taxId":"655819","scientificName":"Beauveria bassiana (strain ARSEF 2860)","fullName":"Beauveria bassiana (strain ARSEF 2860) (White muscardine disease fungus)"},"name":"Nonribosomal peptide synthetase SIDD","description":["Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of at least 11 siderophores, including beauverichelin A, dimerumic acid (DA), Na-dimethyl coprogen (NADC), eleutherazine B, ferricrocin (FC), fusarinine A, fusarinine C (FsC), metachelin A, mevalonolactone, rhodotorulic acid (RA) and tenellin (PubMed:39109629). This cocktail of siderophores for iron metabolism is essential for virulence, and more specifically for the fungal virulence in penetrating through the host cuticle (PubMed:39109629). Siderophore synthesis is also involved in conidial germination under iron-deficient conditions (PubMed:39109629). SIDC catalyzes the assembly of ferricrocin whereas SIDD catalyzes the assembly of fusarinine C (PubMed:39109629)"],"length":1843,"sequence":"MLSIDDHGGGGPLAVDIIPAGSGAQKTAPDAADPSLHGPGRANGDAVNADATAAEETGSRDDESQQQQQQQQQQQQQQQQQRSLLSERDLDQLWQWNAVVPETIQRCIHDIISEQAAQRPQDVAVQSWDGSLTYSELEHLSTQLALHLRLLGVDIGVTVPLCFEKSKWTVVALLAVMKAGAAFSLTDPSQPEARLQTIVEQTGAKLLVTSALQSSLGAKIAPGATVVAVSQATFDTPLQQSSDPLPDVPSSSLMYVIFTSGSTGKPKGVSISHENFTSGAIPRAEAVGYKSTSRVFDFPSYAFDVSIDCMLCTLACGGQVCVPSEQGRMNDLSGSIRDSKANMVHMTPSVARVLDSDIIPSLDVLGLGGEVVSGSDAATWRQFTHLIIGYGPSECTVGCTVNNNTSLSTGIGKGVGCVMWLVDPEDHNVLVPVGEVGELLIEGPVVGIGYLGEPAKTAEVFIEDPTWLTAGHGCYAGRHGRLYKTGDLVRYEDNLSGSIEFVGRKDQQVKIRGQRVELTEVEHHIQTCLPTGVKVVAEVIKPENASPTLVAFLAEKSSVGSQDGSLFVDPSPELSAALDKIDTTLGAKVPKYMIPAAFITLASMPTMVSMKTDRKKLREIGISIPRSKLGATHADEGPQEEPETDAEKKLAHAWQLVLASSSPVYKASSFFGLGGDSLRAMKLVSAAREQGLGLTVADIFNNPTLSAMANKSTSISSATQEQVKPFSLLQEGWDEQTARKDVAELCGIEPEQVEDVYPCTPLQEGLMALSSKVKEAYIAQRVVVLKDLETAKRLMAAYDEASRGSPILRTRIVQVPRRGLMQVVVNRKLEYTTGNNVAAYLASDRETPMDLGTALWRYAIITDEAAGTVSFVLTMHHALYDGWSMPLVVERINQAYQHPGKPLSRPSEFKDFIKYLLSQDAAESEKYWRAQLEGAHRLQFPLLPHQGYQTAADELLEEYVPLEQLPKNATVATLIRAAWAIVASQYINSTDVVFGETLTGRNAPVVGVDEIEGPMITTVPLRVPVDAEAQVGEFLQAIQEQTVGQIPHEHFGLQHIRRLSPDAREACELRAGLVLHPSADTAAPEVDATLPANNLIPHLAAREALKFNTFALMLVCSMDPKGFQVMASFDSKMVDKSTMRRALAQFKSVAQQLAQSTTTLLGNVRALSDDDAAALRDVVATAQEDPVVKTYDGASAAYIVRSDDASKMVPVGAIGELAIQTSQPKDLSTLPVPSWLAALLPPSAPTDALYLTGKLARYDAAGKIQVLGDKASLTASTDASAAARKPRVSATSQRQRRLRALWSHVLRTPETEIGLDDSFFLLGGDSISAMKLASEARPEGIRLTVAQMFSHKTLAEMAAVMECTDESSDSTAAAAAEAPIAPIAEPFELLDGLVDDKSAFLANVVKPQLQDASWTVSNVLPTRFLQELTVRATISKPRFAVRYELIFFDGPVDLRRLRQSCQRLVAHNEILRTVYVESADRIYAAVLDALETPFEEFAYTNPAVDLSTFTKDICRADVDKPQPLGSSFVKWLYVADPQRPAARSCLVFRMSHAQYDEMCLPIMLRQLSALYAHDKTPEPSVPFSAYVSHVMRTAVPASLPYWRELLAGSTITSFRPDIPITDRRHAAIAQTVDISARTRDVTLASLPTATWALCLARRRALRDVVFGEVVSGRNVGLPGAESIAGPCWQYVPLRVRFDPSWTGNDLLAFVQQQHVESAGHEAVSLREIAENCGLGWEKQASMPGDDRPAQWWFDTVCHQDVSHVKERENTDEEAQTKYETLYTDEEPLREWKVQTYVRDGGNSVVLEVVTFKSWEEHGKGLLADLVKAMEQLVHRPGEKLFSD","proteome":"UP000002762","gene":"SIDDA","go_terms":[{"identifier":"GO:0031177","name":"phosphopantetheine binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003824","name":"catalytic activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"659a8cb03cf64c213c74da57ad63126e139952a4","counters":{"domain_architectures":427,"entries":31,"isoforms":0,"proteomes":1,"sets":5,"structures":0,"taxa":1,"dbEntries":{"ssf":3,"cathgene3d":5,"cdd":3,"profile":1,"smart":1,"pfam":3,"panther":1,"ncbifam":1,"prosite":2,"interpro":11},"proteome":1,"taxonomy":1,"similar_proteins":427}}}