{"metadata":{"accession":"I7HD17","id":"I7HD17_9HEPC","source_organism":{"taxId":"31649","scientificName":"Hepatitis C virus subtype 2a","fullName":"Hepatitis C virus subtype 2a"},"name":"Genome polyprotein","description":["Cysteine protease required for the proteolytic auto-cleavage between the non-structural proteins NS2 and NS3. The N-terminus of NS3 is required for the function of NS2 protease (active region NS2-3). Promotes the initiation of viral particle assembly by mediating the interaction between structural and non-structural proteins","Induces a specific membrane alteration that serves as a scaffold for the virus replication complex. This membrane alteration gives rise to the so-called ER-derived membranous web that contains the replication complex. NS4B self-interaction contributes to its function in membranous web formation. Promotes host TRIF protein degradation in a CASP8-dependent manner thereby inhibiting host TLR3-mediated interferon signaling. Disrupts the interaction between STING and TBK1 contributing to the inhibition of interferon signaling","RNA-dependent RNA polymerase that performs primer-template recognition and RNA synthesis during viral replication. Initiates RNA transcription/replication at a flavin adenine dinucleotide (FAD), resulting in a 5'- FAD cap on viral RNAs. In this way, recognition of viral 5' RNA by host pattern recognition receptors can be bypassed, thereby evading activation of antiviral pathways"],"length":3033,"sequence":"MSTNPKPQRKTKRNTNRRPQDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKDRRSTGKSWGKPGYPWPLYGNEGLGWAGWLLSPRGSRPSWGPNDPRHRSRNVGKVIDTLTCGFADLMGYIPVVGAPLGGVARALAHGVRVLEDGVNFATGNLPGCSFSIFLLALLSCITTPVSAAEVKNISTGYMVTNDCTNDSITWQLQAAVLHVPGCVPCEKVGNASQCWIPVSPNVAVQRPGALTQGLRTHIDMVVMSATLCSALYVGDLCGGVMLAAQMFIVSPQHHWFVQDCNCSIYPGTITGHRMAWDMMMNWSPTATMILAYAMRVPEVIIDIISGAHWGVMFGLAYFSMQGAWAKVVVILLLAAGVDARTHTVGGSAAQTTGRLTSLFDMGPRQKIQLVNTNGSWHINRTALNCNDSLHTGFIASLFYTHSFNSSGCPERMSACRSIEAFRVGWGALQYEDNVTNPEDMRPYCWHYPPRQCGVVSAKTVCGPVYCFTPSPVVVGTTDRLGAPTYTWGENETDVFLLNSTRPPLGSWFGCTWMNSSGYTKTCGAPPCRTRADFNASTDLLCPTDCFRKHPDTTYLKCGSGPWLTPRCLIDYPYRLWHYPCTVNYTIFKIRMYVGGVEHRLTAACNFTRGDRCNLEDRDRSQLSPLLHSTTEWAILPCSYSDLPALSTGLLHLHQNIVDVQFMYGLSPALTKYIVRWEWVILLFLLLADARVCACLWMLILLGQAEAALEKLVILHAASAASCNGFLYFVIFFVAAWYIKGRVVPLATYSLTGLWSFSLLLLALPQQAYAYDASVHGQIGAALLVMITLFTLTPGYKTLLGQCLWWLCYLLTLGEAMIQEWVPPMQVRGGRDGIAWAVTIFCPGVVFDITKWLLALLGPAYLLRAALTHVPYFVRAHALIRVCALVKQLAGGRYVQVALLALGRWTGTYIYDHLTPMSDWAASGLRDLAVAVEPIIFSPMEKKVIVWGAETAACGDILHGLPVSARLGQEILLGPADGYTSKGWKLLAPITAYAQQTRGLLGAIVVSMTGRDKTEQAGEIQVLSTVTQTFLGTTISGVLWTVYHGAGNKTLAGSRGPVTQMYSSAEGDLVGWPSPPGTKSMEPCTCGAVDLYLVTRNADVIPARRRGDKRGALLSPRPLSTLKGSSGGPVLCPRGHVVGIFRAAICSRGVAKSIDFIPVEAIDIVTRSPTFTDNSTPPAVPQTYQVGYLHAPTGSGKSTKVPVAYAAQGYKVLVLNPSVAATLGFGAYLAKAHGINPNIRTGVRTVTTGEAITYSTYGKFLADGGCAGGAYDIIICDECHATDATTLLGIGTVLDQAESAGVRLTVLATATPPGSITTPHPNIEEVALGQEGEIPFYGRAIPLAHIKGGRHLIFCHSKKKCDELAAALRAMGLNAVAYYRGLDVSIIPAQGDVVVVATDALMTGYTGDFDSVIDCNVAVTQVVDFSLDPTFTISTQTVPQDAVSRSQRRGRTGRGRLGIYRYVSTGERASGMFDSVTLCECYDAGAAWYDLTPAETTVRLRAYFNTPGLPVCQDHLEFWEAVFTGLTHIDAHYLSQTKQAGENFAYLTAYQATVCARAKAPPPSWDVMWKCLTRLKPTLVGPTPLLYRLGSVTNDVTFTHPVTKYIATCMQADLEVMTSTWVLAGGVLAAIAAYCLATGCVSIIGRLHVNQRTVVAPDKEVLYEAFDEMEECASRAALIEEAQRIAEMLKSKIQGLLQQASKQAQDIQPTVQASWPKVEQFWAKHMWNFISGIQYLAGLSTLPGNPAVASMMAFSAAITSPLSTSTTILLNIMGGWLASQIAPPAGATGFVVSGLVGAAIGSVGLGKVLVDILAGYGAGISGALVAFKIMSGEKPSMEDVINLLPGILSPGALVVGVICAAILRRHVGPGEGAVQWMNRLIAFASRGNHVAPTHYVTESDASQRVTQLLGSLTITSLLRRLHNWITEDCPTPCNGSWLRDVWDWVCTILTDFKNWLTSKLFPKLPGLPFISCQKGYRGDWAGTGIMVTRCPCGANISGNVRFGSMRITGPKTCMNTWQGTFPINCYTEGQCMPRPAPNFKTAIWRVAASEYAEVTRHGSYSYITGLTADNLKVPCQIPSPEFFSWVDGVQIHRFAPTPKPFFRDEVSFSVGLNSFVVGSQLPCDPEPDADVLMSMLTDPGHITAEAAARRLARGSPPSEASSSASQLSAPSLRATCATHGTAYDVAMVDANLFMKGEVIRIESDSKVVVLDSLDPLAEEVSDVEPSIPSEYLIPKKQFPPALPAWARPDYNPPLVESWRKPDYQPPTVAGCALPPPKKTPTPPPRKRRTVRLSESAVGDILQQLAIKTFGQPPPSGGPDPPTGAGAAGSGGQTPPDEPAPSETDSVSSMPPLEGEPGDPDLELGQVEPQPPPQGGEAAPDSDSGSWSTCSEEEDSTVCCSMSYSWTGALITPCSPEEEKLPINPLSNSLLRYHNKVYCTTSRSASLRAKKVTFDRMQVLDAHYDSVLKDIKLAASKVSARSLSLEEACKLTPPHSARSKYGFGAKEVRSLSGRAVNHIKSVWKDLLEDSQTPIPTTIMAKNEVFCVNPAKGGKKAARLIVYPDLGVRVCEKMALYDVAQKLPQAVMGASYGFQYSPAQRVEFLLKAWADKKDPMGFSYDTRCFDSTVTERDIRTEEDIYLSCSLPEEARTATHSLTERLYVGGPMFNSKGQTCGYRRCRASGVLTTSMGNTITCYVKALAACKAAGIVAPTMLVCGDDLVVISESQGTEEDERNLRAFTEAMTRYSAPPGDPPRPEYDLELITSCSSNVSVALGPRGNRRYYLTRDPTTPIARAAWETVRHSPVNSWLGNIIQYAPTIWVRMVLMTHFYSILMAQDTLDQNLNFEMYGAVYSVSPLDLPAIIEKLHGLDAFSLHTYSPNELTRVASALRKLGAPPLRAWKSRARAVRASLISRGGRAAVCGRYLFNWAVKTKLKLTPLPEARHLDLSSWFTVGAGGGDIYHSVSRARPRLLLLSLLLLFVGVGLFLLPAR","proteome":null,"gene":null,"go_terms":[{"identifier":"GO:0004197","name":"cysteine-type endopeptidase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008236","name":"serine-type peptidase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006508","name":"proteolysis","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0019087","name":"symbiont-mediated transformation of host cell","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0008270","name":"zinc ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003968","name":"RNA-directed RNA polymerase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0039694","name":"viral RNA genome replication","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005198","name":"structural molecule activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0019028","name":"viral capsid","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0019031","name":"viral envelope","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0016032","name":"viral process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0044423","name":"virion component","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0004252","name":"serine-type endopeptidase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0017111","name":"ribonucleoside triphosphate phosphatase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003723","name":"RNA binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"fdbbd0c975d426b11f7f585a94169a6b41e4c969","counters":{"domain_architectures":26,"entries":67,"isoforms":0,"proteomes":0,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":14,"cdd":2,"profile":5,"ssf":3,"pfam":14,"smart":2,"interpro":27},"proteome":0,"taxonomy":1,"similar_proteins":26}}}