{"metadata":{"accession":"I3MP25","id":"I3MP25_ICTTR","source_organism":{"taxId":"43179","scientificName":"Ictidomys tridecemlineatus","fullName":"Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)"},"name":"Synembryn","description":["Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity: folds GNAI1, GNAO1, GNA13 and GNAQ. Does not fold G(s) G-alpha proteins GNAS nor GNAL. Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (GNAI1), possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation","Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation. Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP"],"length":530,"sequence":"MEPRAVADALETGKEDVITEALRTYNREHSQSFTFDEAQQEDRKRLAELLVTVLEQGLPPSHRVTWLQTVRILSRDRSCLDPFTSRQSLHALACYAGISASEGSVPESPDMDVILESLKCLCNLVLSSPVAQTLAAEAHLVVRLAERVGTYSKKSFPHDVQFFDLRLLFLLTALRTDVRQQLFQELHGVHLLTHTLELTLGMTPEESPPDLLPPQETERAMEILKVLFNITFDSIKREVDEEDTALYQYLGTLLRHCVMVAAAGDRTEEFHGHTVNLLGNLPLKCLDVLLALELHEGSLEFMGVNMDVIGVLLAFLEKRLHQTHRLKESVAPVLSVLTECARMHRPVRKFLKAQVLPPLRDVRTRPEVGELLRNKLVRLMTHLDTDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSEDEDTDTDEYKEAKASINPVTGRVEEKPPNPMEGMTEEQKEHEAMKLVNMFDKLSRHRVIQPMGMSPRGHLTSLQDAMCETMEGQLSSDPDSDPD","proteome":"UP000005215","gene":"RIC8A","go_terms":null,"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"75915d1d069a341bf0e426c0b7060a71405751d2","counters":{"domain_architectures":5302,"entries":9,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"panther":1,"pfam":1,"prints":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":5302}}}