{"metadata":{"accession":"I3KG55","id":"I3KG55_ORENI","source_organism":{"taxId":"8128","scientificName":"Oreochromis niloticus","fullName":"Oreochromis niloticus (Nile tilapia)"},"name":"Cell cycle checkpoint control protein RAD9A","description":["Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity"],"length":406,"sequence":"MNCVLEGNSIKAFGKAIHALSRVGDELWLDPMVKGLALRSVNSAHSAYACFLFSPLFFQQYSLDSVRQQDSGPIKCKLVMKSVLPLFRCSTSIERSVKQCQISVSTGSDRVIIQFFCRHGITKTYNVRFLESEALQAVFASHLCPNVLKAPARLLGNMVKHFHASQEEVTLSMSALRVSLRNYNEGRNDHMKMMHTEMSLHPDEFDYFQAGVDSDITFCLKELRGLLCFAESHCLPVSVHFGAPGKPVCFSVEDMVLEATVVLATLADFESRGPSQPTETPAPTTHSCADAAALPVGIHETQSNNLQVLPDVTELVESSQGSPITYPPVLMQLQCQGDNLAELCVPAEACACAGMTPPSSMICSLLFKALSSELGDDDDYDDGGAPRLPVLAYFSDEEDYPRSPSL","proteome":"UP000005207","gene":"rad9b","go_terms":[{"identifier":"GO:0000077","name":"DNA damage checkpoint signaling","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0030896","name":"checkpoint clamp complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"907a45f8ede2d4cfef0e1994f71b50f31f0ac93f","counters":{"domain_architectures":5081,"entries":7,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"cdd":1,"ssf":1,"panther":1,"pfam":1,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":5081}}}