{"metadata":{"accession":"H9G667","id":"H9G667_ANOCA","source_organism":{"taxId":"28377","scientificName":"Anolis carolinensis","fullName":"Anolis carolinensis (Green anole)"},"name":"Peroxisomal coenzyme A diphosphatase NUDT7","description":["Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Cleaves CoA, CoA esters and oxidized CoA with similar efficiencies. Preferentially hydrolyzes medium-chain acyl-CoAs and bile acid-CoAs. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. Exhibits decapping activity towards dpCoA-capped RNAs in vitro"],"length":239,"sequence":"MAAAEVSVEDWRRMDVKDKAKLQLKKFDIGERFSHFPGGKASVLLPLMVKDGKLHLLFTVRSMQLRRSPGDVCFPGGRREPTDKDEIDTALRESQEEIGLHPEQAEVICRLVPVLDKTDSLVTPVVAFIEDTFHAHPNPEEVSDTFSMPLEYFIRPSKYNGITVPLNGIPYLMHTFEYDDPEHKRSFKIVGLTAHIAVFLALAVFGEKPTFEVPYDLENLNSSAVNLFLERYKKAKSKL","proteome":"UP000001646","gene":"NUDT7","go_terms":[{"identifier":"GO:0010945","name":"coenzyme A diphosphatase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0000287","name":"magnesium ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016818","name":"hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0030145","name":"manganese ion binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"752b3b6d9807717ea1f029db1420a2538cb188ca","counters":{"domain_architectures":250306,"entries":11,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"profile":1,"cdd":1,"pfam":1,"panther":1,"prosite":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":250306}}}