{"metadata":{"accession":"H6BPK3","id":"H6BPK3_EXODN","source_organism":{"taxId":"858893","scientificName":"Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656)","fullName":"Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656) (Black yeast)"},"name":"Actin cytoskeleton-regulatory complex protein END3","description":["Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization"],"length":412,"sequence":"MSGSKRIEKWEIDRYWEIFSSLVQPPATSASHLTNQAAANVLRNSQLRDDQLERVWDLADVDGDGELDFEEFCVAMRLIFDLVNGEYQDVPKSLPDWLVPESKAHLVAANRALTGDRREQFERIEDDEDDAGLKDGFDWYMSPEDKHKYEEIYSANKDRRGEISFDSLQGLYASLDVPDTDIRSAWNLINTSGRDTISKDACLAFLHILNYRHEGYRIPRTVPPSLRASFEGNQIDYQIDSMRNRPNKYDEETPTGRKSKFGDAYLSRLGARGGSAYTPKGTDFSDVVEDEDLEKVRLLRELRELEAQHDAAIAAAERRRKQRQENGGGRQPGKTNWTLVKREAQQLLEYKRRQYLELNSETANKSGTDLKRLRDDLALVAEQIDGLESHLKKRQAELDNLRQEIENEKASR","proteome":"UP000007304","gene":"HMPREF1120_01794","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005509","name":"calcium ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006897","name":"endocytosis","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0007015","name":"actin filament organization","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"485a3a6bb3dfcff7f3bc3b18f8ddad09c4c2d1f8","counters":{"domain_architectures":1206,"entries":16,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"smart":2,"ssf":1,"pfam":2,"profile":2,"cdd":1,"panther":1,"prosite":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":1206}}}