{"metadata":{"accession":"H2P541","id":"H2P541_PONAB","source_organism":{"taxId":"9601","scientificName":"Pongo abelii","fullName":"Pongo abelii (Sumatran orangutan)"},"name":"Metalloendopeptidase","description":["Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding"],"length":436,"sequence":"MEGVGGLWPWVLGLLSLPGVILGAPLASSCPGACGTSFPDGLTPEGTQASGDKDIPAINQGLIPEETPESSFLIEGDIVRPSPFRLLSATSNKWPTGGGGVVEVPFLLSSKYGECKYDEPNRQVILEALAEFERSTCIRFVAYQGQRDFISIIPMYGCFSSVGRSGGMQVVSLAPTCLQKGRGIVLHELMHVLGFWHEHARADRDRYIRVNWNEILPGFEINFIKSRSSNMLTPYDYSSVMHYGRLAFSRRGLPTITPLWAPSVHIGQRWNLSASDITRVLKLYGCSPSGPRPRGRGSHAHSTGRSPTPASLSLQQLLEALSAESRSPDPSGSSARGQPIPAGPGESPRGWESPALKKLSAEASARQPQTLASSSRSRPGVGAPGVAQEQSWLAGVPTEPTVPSSEAGIQPVPVQGSPALPGGCVPGNHFKGRSED","proteome":"UP000001595","gene":"ASTL","go_terms":[{"identifier":"GO:0008237","name":"metallopeptidase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004222","name":"metalloendopeptidase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006508","name":"proteolysis","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0008270","name":"zinc ion binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"efeb0259b28ed197c93a8972de3a29c21620a393","counters":{"domain_architectures":19101,"entries":10,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"profile":1,"smart":1,"ssf":1,"pfam":1,"panther":1,"prints":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":19101}}}