{"metadata":{"accession":"H2NKE6","id":"H2NKE6_PONAB","source_organism":{"taxId":"9601","scientificName":"Pongo abelii","fullName":"Pongo abelii (Sumatran orangutan)"},"name":"G protein-coupled receptor kinase","description":["Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination. May play a role in the maintenance of the outer nuclear layer in the retina"],"length":563,"sequence":"MDFGSLETVVANSAFIAARGSFDSGSSQPSRDKKYLAKLKLPPLSKCESLRDSLSLEFESVCLEQPIGKKLFQQFLQSAEKHVPALELWKDIEDYDTADNDLQPQKAQTILAQYLDPQAKLFCSFLDEGTVAKFKEGPVEIQDGLFQPLLQATLAHLGQAPFQEYLGSLYFLRFLQWKWLEAQPMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMKVHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRAVFYTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPDSKTVYAKDIQDVGAFSTVKGVAFDKTDTEFCQEFATGNCPIPWQEEMIETGIFGELNVWRSDGQMPDDMKGISGGSGSSSKSGMCLVS","proteome":"UP000001595","gene":"GRK1","go_terms":[{"identifier":"GO:0050254","name":"rhodopsin kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007601","name":"visual perception","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0022400","name":"regulation of opsin-mediated signaling pathway","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004672","name":"protein kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006468","name":"protein phosphorylation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004674","name":"protein serine/threonine kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004703","name":"G protein-coupled receptor kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007165","name":"signal transduction","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"2ee68e726ca7e7e708bd2aa9646705deedf1d08d","counters":{"domain_architectures":6985,"entries":28,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"ssf":2,"smart":3,"pfam":2,"profile":3,"cdd":1,"panther":1,"prints":1,"prosite":2,"interpro":10},"proteome":1,"taxonomy":1,"similar_proteins":6985}}}