{"metadata":{"accession":"H0XDZ5","id":"H0XDZ5_OTOGA","source_organism":{"taxId":"30611","scientificName":"Otolemur garnettii","fullName":"Otolemur garnettii (Small-eared galago)"},"name":"Cathepsin B","description":["Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE. Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen. Has also been implicated in tumor invasion and metastasis"],"length":339,"sequence":"MWRLLASLCCLLVLTSAWSKPYFHPLSDELVNFINKQNSTWQAGHNFRNVDMSYLKRLCGSFLGGPKLPQRVKFAKDMNLPKSFDAREQWSHCPTIKEIRDQGSCGSCWAFGAVESISDRICIHTNGHVSVEVSAEDLLTCCGGQCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPACTGEGDTPKCSKTCEPGYSPTYKEDKHFGYTSYSLPTNEWEIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHLTGDMMGGHAIRILGWGEENGVPYWLVANSWNTDWGDGGFFRILRGQDHCGIESEVVAGIPRTDQYWEKI","proteome":"UP000005225","gene":"CTSB","go_terms":[{"identifier":"GO:0004197","name":"cysteine-type endopeptidase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0050790","name":"regulation of catalytic activity","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0008234","name":"cysteine-type peptidase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006508","name":"proteolysis","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"f09cbe7b3e5ea5c31f0ef1db4dc59ab56f5d6f2e","counters":{"domain_architectures":3274,"entries":18,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":2,"smart":1,"cdd":1,"panther":1,"prosite":3,"prints":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":3274}}}