{"metadata":{"accession":"H0WQU5","id":"H0WQU5_OTOGA","source_organism":{"taxId":"30611","scientificName":"Otolemur garnettii","fullName":"Otolemur garnettii (Small-eared galago)"},"name":"Thioredoxin reductase 3","description":["Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components"],"length":595,"sequence":"RPPEDREEVRRRLMGLIEGNRVMIFSKSYCPYSTRVKELFSSLGIGCNILELDQIDDGANVQEVLSEISNQKTVPNIFVNKVHVGGCDRTFQAHQNGLLQKLLQEDSAYDYDLIVIGGGSGGLACAKEAAILGKKVMVLDFVVPSPQGTSWGLGGTCVNVGCIPKKLMHQAALLGQALHDSRKFGWEYNQHVRHSWETMIEAVQNHIGSLNWGYRLSLREKSVAYVNSYGEFVEHHKIKATNRKGQETCYTAAKFVIATGERPRYLGIQGDKEYCITSDDLFSLPHCPGKTLVVGASYVALECAGFLAGLGLEVTVMVRSVLLRGFDQEMAEKVGSYMEQHGVKFLRKFVPVMVQQLEKGSPGKLKVSAKSTEGPETIEGIYNTLLIFVISDPCTRKIGLEKIGVKINEKNGKIPVNDVEQTNVPYVFAIGDVLEGKPELTPVAIQAGKLLARRLFGAASEKCDYVNIPTAVFTPLEYGCCGLSEEKAVEAYKKENLEVFHSFFWPLEWTLAGRDNNTCYAKIICNKLDHDRIIGLHILGPNAGEVTQGFAAAMKCGLTKQQLDDTIGIHPTCGEVFTALEITKSSGLDITQKGC","proteome":"UP000005225","gene":null,"go_terms":[{"identifier":"GO:0016491","name":"oxidoreductase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0050660","name":"flavin adenine dinucleotide binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0045454","name":"cell redox homeostasis","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004791","name":"thioredoxin-disulfide reductase (NADPH) activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016668","name":"oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"c6e7786c4de746e322561b18292160cad8bf5ee7","counters":{"domain_architectures":1152,"entries":27,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"profile":1,"ssf":3,"cdd":1,"pfam":3,"ncbifam":2,"panther":1,"prints":2,"prosite":1,"interpro":10},"proteome":1,"taxonomy":1,"similar_proteins":1152}}}