{"metadata":{"accession":"G7NPI8","id":"G7NPI8_MACMU","source_organism":{"taxId":"9544","scientificName":"Macaca mulatta","fullName":"Macaca mulatta (Rhesus macaque)"},"name":"DnaJ homolog subfamily A member 3, mitochondrial","description":["Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway"],"length":480,"sequence":"MAARCSTRWLLVAVGTPRLPAALGRGARPPREGVVGAWLSRKLSVPAFASSLTSRGPRALLTLRPGVSLTGTIHYPFISTASFHTNAPLAKEDYYQILGVPRNASQKEIKKAYYQLAKKYHPDTNQDDPKAKEKFSQLAEAYEVLSDEVKRKQYDAYGSAGFDSGASGSQHSYWKGGPTVDPEELFRKIFGEFSSSSFGDFQTVFDQPQEYIMELTFNQAAKGVNKEFTVNIMDTCERCDGKGNEPGTKVQHCHYCGGSGMETINTGPFVMRSTCRRCGGRGSIIVTPCVVCRGVGQAKQKKRVMIPVPAGVEDGQTVRMPVGKREIFITFRVQKSPVFRRDGADIHSDLFISIAQALLGGTARAQGLYETINVMIPPGTQTDQKIRMGGKGIPRINSYGYGDHYIHIKIRVPKRLTSRQQNLILSYAEDETDVEGTVNGVTLTTSGGSSMDSSAGSKARREAGEDEEGFLSKLKKMFTS","proteome":null,"gene":"EGK_12449","go_terms":[{"identifier":"GO:0031072","name":"heat shock protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0051082","name":"unfolded protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006457","name":"protein folding","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0009408","name":"response to heat","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"009a4105d0b2ae9aa2aa7435e492b440f6147828","counters":{"domain_architectures":35801,"entries":28,"isoforms":0,"proteomes":0,"sets":5,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"ssf":3,"smart":1,"cdd":3,"pfam":3,"profile":2,"panther":1,"hamap":1,"prints":1,"prosite":1,"interpro":9},"proteome":0,"taxonomy":1,"similar_proteins":35801}}}