{"metadata":{"accession":"G7MQ47","id":"G7MQ47_MACMU","source_organism":{"taxId":"9544","scientificName":"Macaca mulatta","fullName":"Macaca mulatta (Rhesus macaque)"},"name":"Iodotyrosine deiodinase 1","description":["Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine. During thyroid hormone biosynthesis, facilitates iodide salvage by catalysing the oxidative NADPH-dependent deiodination of the halogenated by-products of thyroid hormone production, monoiodotyrosine (L-MIT) and diiodotyrosine (L-DIT). The scavanged iodide can then reenter the hormone-producing pathways. Acts more efficiently on 3-iodo-L-tyrosine than 3,5-diiodo-L-tyrosine"],"length":293,"sequence":"MFFLTPILVAILCILVVWIFKNADRHMEKKKGEPRAIAEARPWVDEDLKDSSDLHQAEEDADEWQESEESVEHIPFSHTHYPEKEMVKRSQEFYELLNRRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINYMKRMGHRWVTDLKKLRTNWIKEYLDTAPILILIFKQVHGFAANGKKKVHYYNEISVSIACGILLAALQVNNGITTRRQTAGHRYLIEGPGRSSEACSKLSSQGCPECRSGDCHYHSSQLWPSTEGAPGPPRT","proteome":null,"gene":"EGK_15255","go_terms":[{"identifier":"GO:0016491","name":"oxidoreductase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"dac50674d5c2b21f2c67165d4146e17fa4ed7c02","counters":{"domain_architectures":82232,"entries":8,"isoforms":0,"proteomes":0,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"cdd":1,"pfam":1,"panther":1,"interpro":3},"proteome":0,"taxonomy":1,"similar_proteins":82232}}}