{"metadata":{"accession":"G3WN93","id":"G3WN93_SARHA","source_organism":{"taxId":"9305","scientificName":"Sarcophilus harrisii","fullName":"Sarcophilus harrisii (Tasmanian devil)"},"name":"Trifunctional enzyme subunit beta, mitochondrial","description":["Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities, while the trifunctional enzyme subunit beta/HADHB described here bears the 3-ketoacyl-CoA thiolase activity"],"length":473,"sequence":"MTSILTRTLRNLPLTYTWATKFPLRSLTTSQPLTTAAQTQSKKTLTKPNVKNIVVVDGVRIPFLLSGTTYKDLMPHDLARAALKGLLHRTNIPKDSVDYIVYGTVIQEVKTSNVAREAALGAGFSDKIPAHTVTMACISSNQAMTTGFGLIASGQYDVVVAGGVELMSDVPIRHSRKMRKLMLELNKAKTLGQRLSVASKFRLNFLAPELPAVAEFSTSETMGHSADRLAAAFSVSRAEQDEYALRSHSLAKQAQEQGLLTDVIAFKVPGKDTVTKDNGIRPSSLEQMAKLKPAFVKPYGTVTAANSSFLTDGASAMLIMSEEKALALGYKPKAYLRDFVYVSQDPKDQLLLGPTYATPKVLEKAGLTLKDIDVFEFHEAFSGQILANFKAMDSDWFAQNYMGRKSKIGAPPLEKFNTWGGSLSLGHPFGATGCRLVMAAANRLRKDGGQYGLVAACAAGGQGHAMIVEAYPK","proteome":"UP000007648","gene":"HADHB","go_terms":[{"identifier":"GO:0016746","name":"acyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016747","name":"acyltransferase activity, transferring groups other than amino-acyl groups","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"22ac5442f852b2fb09958cfc4b5d4345c679ae38","counters":{"domain_architectures":119306,"entries":17,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":2,"cdd":1,"panther":1,"ncbifam":1,"prosite":3,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":119306}}}