{"metadata":{"accession":"G3WF21","id":"G3WF21_SARHA","source_organism":{"taxId":"9305","scientificName":"Sarcophilus harrisii","fullName":"Sarcophilus harrisii (Tasmanian devil)"},"name":"Tudor domain-containing protein 3","description":["Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1"],"length":746,"sequence":"MAEVPSAALSQAGWYLSDEGIEACKSSPDKVNINDIILIALNTDLRTIGKKFLPSDINGGKVEKLEGPCVLQIQKIRNVAAPKDNEESQVAPRMLRLQMTDGHISCTAVEFNYMSKISLNTPPGTKVKLSGIIDIKNGFLLLNDSNTVVLGGEVEHLIEKWELQRSLSKHNRSNIGTEGGPPPFVPFGQKCVSHVQVDSRELDRRKTLQVTAPAKPSGDNDEFEKQRTAAIAEVSKGKETKTFGGGGGNARSNLNMSTGGNRNREVFQKEKITKPEGKYEGVYRELVDEKALKHITEMGFSKEASRQALMDNGNNLEAALNVLLNSNKQKPVLGPPMRGKGKGRGRGRCEDEEELGNSRPSAPSTLFDFLESKMGSLNMEESKAQSQPLHQGQHRLLNNEQNGVKDYNQPRHLPRNDTRQPRNEKPPRFQRDTQNSRQILENSGLPRSRGPERQSSSVVHEAWTEERIKCDRPYARNDRIKDIAYPSTSHQNDGAFKKRDNSMQNRPGKGPSYLEVKESPLPQETIDHNNQKRGKRENQISNPDQLYERKTRTISNEAFSGMKNEKHFNMNTDYPNSVRTDGFSGVPNGEVEVSMKGRRVGPIKSAGSTGAPAFDDKMLFYNSGPKRRSGPIKPEKVLESSLPVECGRMWKPGDECFALYWEDNKFYRAEIEALHSSGMTAVVKFSDYGNYEEVLLSNIRPIQAEAWEEEEGTYDQTLEFRRGGDGQPRRSTRPTQQFYQPPRARN","proteome":"UP000007648","gene":"TDRD3","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"101efcae90293ba71cb14a22640ea36400362780","counters":{"domain_architectures":742,"entries":23,"isoforms":0,"proteomes":1,"sets":5,"structures":0,"taxa":1,"dbEntries":{"smart":3,"cathgene3d":3,"pfam":3,"ssf":2,"profile":2,"cdd":2,"panther":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":742}}}