{"metadata":{"accession":"G3UN24","id":"G3UN24_LOXAF","source_organism":{"taxId":"9785","scientificName":"Loxodonta africana","fullName":"Loxodonta africana (African elephant)"},"name":"Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma","description":["Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3"],"length":422,"sequence":"MASSSAPPATVSTATAGPGPGFGFASKTKKKHFVQQKVVFRAADPLVGVFLWGVAHFAKINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRSPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDCYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKVFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEGPAREEDAEGEGDCGLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGAEISTVHPEQYAKRFLDFITNIFA","proteome":"UP000007646","gene":"PIP4K2C","go_terms":[{"identifier":"GO:0052742","name":"phosphatidylinositol kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0046488","name":"phosphatidylinositol metabolic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"13ff713099661d6f671208a113c5ca8bd615df76","counters":{"domain_architectures":19884,"entries":12,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"profile":1,"cdd":1,"ssf":1,"smart":1,"panther":1,"pfam":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":19884}}}