{"metadata":{"accession":"G3T2V0","id":"G3T2V0_LOXAF","source_organism":{"taxId":"9785","scientificName":"Loxodonta africana","fullName":"Loxodonta africana (African elephant)"},"name":"Nuclear factor of activated T-cells 5","description":["Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3'. Mediates the transcriptional response to hypertonicity. Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17. Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA"],"length":1454,"sequence":"MSQTSGGEAGSPPPAVVAADASSAPSSSMGGPCSSFTTSSSPTIYSTSVTDSKAMQVESCSSAVGVSNRGVSEKQLTSNTVQQHPSTPKRHTVLYISPPPEDLLDNSRMSCQDEGCGLESEQSCSMWMEESPSNFSNMSTSSYNDNTEVPRKSRKRNPKQRPGVKRRDCEESNMDIFDADSAKAPHYVLSQLTTDSKGNSKAGNGTLENQKGAGVKKSPMLCGQYPVKSEGKELKIVVQPETQHRARYLTEGSRGSVKDRTQQGFPTVKLEGHNEPVVLQVFVGNDSGRVKPHGFYQACRVTGRNTTPCKEVDIEGTTVIEVGLDPSNNMTLAVDCVGILKLRNADVEARIGIAGSKKKSTRARLVFRVNITRKDGSTLTLQTPSSPILCTQPAGVPEILKKSLHSCSVKGEEEVFLIGKNFLKGTKVIFQENVSDENSWKSEAEIDMELFHQNHLIVKVPPYHDQHITLPVSVGIYVVTNAGRSHDVQPFTYTPDPATASALNVNVKKEISSPARPCSFEEAMKAMKTTGCNLDKVNILPNALIPPLISSSMIKSEDVTPMEVTAEKRSSPIFKNTKPVGSTQQTLETISNIAGNGSFSSSSSSHLPSENEKQQQIQPKAYNPETLTTIQTQDISQPGTFPAVSASSQLPNSDALLQQATQFQTRETQSREVLQSDGTVVNLSQLTEASQQQQQSPLQEQAQTLQRQMSSNIFPSPNSVSQLQNTIQQLQAGSFTGSTTSGSGGNVDLVQQVLEAQQQLSSVLFSAPDGNENVQEQLSADIFQQVSQIQNSVSPGMFSSTEPAVHTRPDNLMPGRAENVHPQSENTLSKVMESSAAMVMEMQQSICQAAAQIQSELFPSTASANGNLQQSPVYQQTSHMMSALSTNEDMQIQCELFSSPPAVSGKETSATTTQQVATPGTTMFQTSSSGDGEETGAQAKQIQNSVFQTMVQMQHSGDSQPQVTLFSSTKSMMSVQNSGTQQQGNGLFQQGNEMMSLQSGSFLQQSAHSQAQLFHPQNPIADAQNLSQETQGSLFHSPSPIVRSQTSTTSSEQMQPPMFHSQSTITVLQGSSQDQQPTNIFLSQSPLNNLQTNTVAQEEQISFFAAQNSISPLQSTSSTEQQAAFSQQASISHIQTPMLSQEQAQPSQQGLFQPQVSLGSLPPNPMPQNQQGTIFQSQHSMVAIQSSSPSLLFSNQNTMATMASQKQPPPNMIFNPNQNPMANQEQQNQSIFHQQNNMAPMNQEQQPMQFQNQPTVSSLQNPGSTQSESPQTSLFHTSPQIQLVQGSPSSQEQQVTLFLSPASMSALQTSINQQDMQQSPLYSPQNSMPGIQGATSSPQPQATLFHNTAGGTMNQLQNSPGSSQQTSGMFLFGIQNNCSQLLTSGPAALPDQLMAISQAGQPQNEGQPPVTTLLSQQMAENSPLASSINTNQNMEKMDLLVSLQNQGNNLTGSF","proteome":"UP000007646","gene":"NFAT5","go_terms":[{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003700","name":"DNA-binding transcription factor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006355","name":"regulation of DNA-templated transcription","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0000978","name":"RNA polymerase II cis-regulatory region sequence-specific DNA binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"in_bfvd":false,"ida_accession":"6c53731a86129dfa6705260cbbb19e680bcde41a","counters":{"domain_architectures":10875,"entries":21,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"profile":1,"cathgene3d":2,"ssf":2,"cdd":2,"pfam":2,"smart":1,"panther":1,"prints":1,"interpro":9},"proteome":1,"taxonomy":1,"similar_proteins":10875}}}