{"metadata":{"accession":"G3T067","id":"G3T067_LOXAF","source_organism":{"taxId":"9785","scientificName":"Loxodonta africana","fullName":"Loxodonta africana (African elephant)"},"name":"Nuclear receptor-binding factor 2","description":["Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy. Stabilizes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3. Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1. May be involved in autophagosome biogenesis. May play a role in neural progenitor cell survival during differentiation","May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro)"],"length":288,"sequence":"MEVMEGPLNLAHQQSRRADRLLAAGKYEEAISCHKKAAAYLSEAMKLTQSEQAHLSLELQRDSHMKQLLLIQERWKRAKREERLKAQQSTDRDIANYLQASHRPSAEDAEGQSPLVLQKGSPSTEKHLPENQRVFDRDPDTLLFLLQQKSEPTEPCIGSKAPKDDKTIIEEQATKIAALKRHVEFLVAENERLRKENKQLKAEKARLLKGPVEKELDVDADFVETSELWSLPPHSETPAVSSTWQEFATNSGKAKDIPIPNLPPLDFPSPELPLMELSEDILKGLMNN","proteome":"UP000007646","gene":"NRBF2","go_terms":[{"identifier":"GO:0006914","name":"autophagy","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"7554e71c3ca00fab3156fcb8d1f73b85de366e72","counters":{"domain_architectures":1036,"entries":8,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"pfam":2,"ssf":1,"panther":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":1036}}}