{"metadata":{"accession":"G1TUA4","id":"G1TUA4_RABIT","source_organism":{"taxId":"9986","scientificName":"Oryctolagus cuniculus","fullName":"Oryctolagus cuniculus (Rabbit)"},"name":"Cytosolic arginine sensor for mTORC1 subunit 1","description":["Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway"],"length":314,"sequence":"LGEETSAWRRRVLLNASRPPPTRCKFFSLTETPEDYTLMVDDEGFKELPPSEFLQVAEATWLVLNVSSSSGAAVQAAGVTKIARSVIAPLAEHHVSVLMLSTYQTDFILVREQDLSVVIHTLAQEFAIYREVGGEAVPVVRDDSSNGFPRAQHGPSPTVHPIQSPQNRFCVLTLDPETLPAIAITLIDVLFYSHSTPKEPASGSLESSSIPFFAFSLIEGYISIVMDAETQKKFPSDLLLTSSSGELWRMVRIGGQPLGFDECGIVAQIAGPLAAADISAYYISTFNFDHALVPEDGISNVIEVLQRRQEGLAP","proteome":"UP000001811","gene":"CASTOR1","go_terms":null,"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"86e2f292e9d15d90cb6253b7ab58cc4daf0a1d43","counters":{"domain_architectures":1330,"entries":13,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"pfam":3,"ssf":1,"panther":1,"prints":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":1330}}}