{"metadata":{"accession":"G1LUU4","id":"G1LUU4_AILME","source_organism":{"taxId":"9646","scientificName":"Ailuropoda melanoleuca","fullName":"Ailuropoda melanoleuca (Giant panda)"},"name":"RAS guanyl-releasing protein 4","description":["Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting Ras-mediated activation of PIK3CG/PI3Kgamma to promote neutrophil functional responses. In CD117(+) dendritic cells and mast cells, participates in an lipopolysaccharide (LPS)-activated signaling pathway that stimulates the production of interferon-gamma and other pro-inflammatory cytokines by natural killer (NK) cells. May function in mast cell differentiation. Does not appear to be required for the development of B-cells, DC-cells, T-cells, or NK-cells"],"length":673,"sequence":"MNRKDSKRKSHQECPGKTGGRGRPRQARRHKTCPSPREISKVMASMALGMLNEGGCSEDELLEKCIQSFDSAGSLRHGDHILNMVLAMHSWVLPSAHLAARLLTLYQEATGNTQEQRRLQICHLVRYWLTQHPETVHQEPQLEEVIGRFWATVEQEGNSAQRSLGDSSNLLSPGGPGPPPPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRGYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPAQRAQVLDKFIQVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELSELLAAHNNYARYRRTWADCTGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELAALQRQHPPCGASEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFKAPLVVEWAPGVTPKPDRATLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPHQGNGSYSREELTGYLLRASAICSKLGLAFLHNFQEVTFRKPTFCDSCSGFLWGVTKQGYRCRDCGLCCHKHCRDRVKVECKKRPGAKGDMSPPGAPVPPTLVPHASCGSEDNLSYTLSLEPETGCHLCHAWTQTEPPHPSWEPEMVPLPTTASPPAQSSKLNS","proteome":"UP000008912","gene":"RASGRP4","go_terms":[{"identifier":"GO:0005085","name":"guanyl-nucleotide exchange factor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0007264","name":"small GTPase-mediated signal transduction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005509","name":"calcium ion binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"303b1c473b1040b5e9cf088ff2879651fe29d6f1","counters":{"domain_architectures":1476,"entries":29,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":4,"profile":4,"ssf":2,"cdd":3,"smart":2,"pfam":2,"panther":1,"prints":1,"prosite":1,"interpro":9},"proteome":1,"taxonomy":1,"similar_proteins":1476}}}