{"metadata":{"accession":"G1L781","id":"G1L781_AILME","source_organism":{"taxId":"9646","scientificName":"Ailuropoda melanoleuca","fullName":"Ailuropoda melanoleuca (Giant panda)"},"name":"Activating signal cointegrator 1","description":["Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation. Also involved in androgen receptor transactivation. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B. May play a role in the development of neuromuscular junction. May play a role in late myogenic differentiation. Also functions as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation"],"length":581,"sequence":"MAVAGAASREQLVGWCTQQLRKTFGLDVSEEIMQYVLSIESAEEIREYVTDLLQGNEDKKGQFIEELIMKWQKNDQELSSDALQQSFKKDEMLDGQRSGDQLKRSRRKGRNRQEVPAFAEPDTTREVKTPFDLAKAQENSNSLKKKTKFVSLYTKEGQDRLAVLIPGRHPCDCLGQKHKLINNCLICGRIVCEQEGSGPCFFCGTLVCTREEQDILQRDSNKSQKLLKKLMSGTENSGKADISTKDLLPHQELRIKSGLEKAIKHKDKLLEFDRTSIRRTQVIDDESDYFASDSNQWLSKIERETLQKREEELREFRHMSRLSKKITIDFAGRKIVEDENPLAEYHSKLDETIQAIANGTLNQPLTKLDRSSDEPLGVLVNPNLYQSPPQWIDQTGAASQKKAFRSAGSELEFNSYRHQLRIQDQEFQEGFDGGWCLSMHQPWASLLVRGIKRVEGRSWYTPHRGRLWIAATAKRPSPQEVSELQTTYRVLRGKDVEFPNDYPSGCLLGCVDLIDCLSQKEFKDQYPDMSQESDSPFVFICTNPQEMIVKFPIKGNPKIWKLDSKIHQGAKKGLMKQNKAV","proteome":"UP000008912","gene":"TRIP4","go_terms":[{"identifier":"GO:0008270","name":"zinc ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0072344","name":"rescue of stalled cytosolic ribosome","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005634","name":"nucleus","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0180022","name":"RQC-trigger complex","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"978ebd5b7de0ff1cc5e194c9c293b90550b4897f","counters":{"domain_architectures":1265,"entries":15,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"pfam":4,"ssf":1,"cdd":1,"cathgene3d":1,"smart":1,"panther":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":1265}}}