{"metadata":{"accession":"F7HPE9","id":"F7HPE9_MACMU","source_organism":{"taxId":"9544","scientificName":"Macaca mulatta","fullName":"Macaca mulatta (Rhesus macaque)"},"name":"Prostaglandin E synthase 2","description":["Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro). The biological function and the GSH-dependent property of PTGES2 is still under debate. In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA)"],"length":377,"sequence":"MAPATRVVRALWTGGCALAWRLGGRPQPLLPTQSRAGFAGAAGGQGPVAAARKGSPRLLGAAALALGGALGLYHTARWHLRAQDLHAERSAVQLSLSSRLQLTLYQYKTCPFCSKVRAFLDFHALPYQVVEVNPVLRAEIKFSSYRKVPILVAQEGESSQQLNDSSVIISALKTYLVSGQPLEEIITYYPAMKAVNDQGKEVTEFGNKYWLMLNEKEAQQVYSGKEARTEEMKWRQWADDWLVHLISPNVYRTPTEALASFDYIVREGKFGAVEGAVAKYMGAAAMYLISKRLKSRHRLQDNVREDLYEAADKWVAAVGKDRPFMGGQKPNLADLAVYGVLRVMEGLDAFDDLMQHTHIQPWYLRVERAITEASPAH","proteome":"UP000006718","gene":"PTGES2","go_terms":[{"identifier":"GO:0050220","name":"prostaglandin-E synthase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":2,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"bbf7d15f6cfff22fc58ef092b4d781e54f882369","counters":{"domain_architectures":15342,"entries":21,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"profile":2,"cdd":2,"ssf":2,"pfam":1,"panther":1,"sfld":3,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":15342}}}