{"metadata":{"accession":"F7EDC6","id":"F7EDC6_MACMU","source_organism":{"taxId":"9544","scientificName":"Macaca mulatta","fullName":"Macaca mulatta (Rhesus macaque)"},"name":"NF-kappa-B inhibitor zeta","description":["Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Also seems to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR)"],"length":930,"sequence":"MWTNFFKLRLFCCLLAVLMVVVLVINVTQVEYLDHETVSATFIDSSGQFISSQVTGISRNPYCGYDQQILSSQERMEEDSLLAALHRQVPDVAPVPFVKSTDPSSSYFVILNSAAFFQVGSQLEVLVHVQDFQRKPKKYGGDYLQARIHSPKLQAGAVGRVVDYQNGFYKVFFTLLWPGKVKVSIFLVHPSEGIRVLQRLQEDKPDRVYFKSLFRSGRISETTECNVCLPGNLPLCNFTDLYTGEPWFCFKPKKLPCSSRITHFKGGYLKGLLTAAESAFFQSGVNIKMPINSSGPDWVTVIPRRIKVEPHMGVGRQQRGPFQGVRVKNSVKELLLHIRSHKQKGSGQAVEDFKTQGVNIEQFREWKNTVSYGGKRKGPDLFSDGPACKRPALLHSQFLTPPQTPTPGESMEDVHHNEPKQDSSADLLQNIINIKNECSPVSLNTVQVSWLNPVVVPQSSPAEQCQDFHGGQVFSPPQKYQPFQVNSPPQVIDQASLYQYSPQNQHVEQQPHYTHKPTLEYSPFSRPPQSPTYEPNLFDGQESPFCPNESLVSFLNNERESENIANPVPTSSSVRQQNDAHLHSFSMTPDSLCEAMAGPEMASDASHTSLPFPNIPGNPMNTTQLGKSFFQWQVEQEESKLANVSQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNLGAQVNTTDCWGRTPLHVCAEKGHCQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPPY","proteome":"UP000006718","gene":"NXPE3","go_terms":[{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0070974","name":"POU domain binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"e3fe834577489e04342e36e9f246e09a15816636","counters":{"domain_architectures":2,"entries":16,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":2,"profile":3,"cathgene3d":1,"smart":1,"pfam":2,"panther":1,"prints":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":2}}}