{"metadata":{"accession":"F7C949","id":"F7C949_XENTR","source_organism":{"taxId":"8364","scientificName":"Xenopus tropicalis","fullName":"Xenopus tropicalis (Western clawed frog)"},"name":"Presenilin","description":["Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors"],"length":451,"sequence":"MITFANSSDSEDDECNERTSLITSQSPPLPSYQDGLQASGGSESSDPMKTQTDTQVIEDVPNGRTSGADAYNSDAAMENEEEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTEKDGQLIYTPFSEDTTSVGQRLLNSVLNTLIMISVIIVMTIFLVLLYKYRCYKFIHGWLILSSLMLLFMFTYIYLSEVFKTYNIAMDYPTLFMVIWNFGAVGMICIHWKGPLQLQQAYLIMISALMALVFIKYLPEWSAWVILGAISVYDLLAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWTVGMADSATADGRMNQQVQRTERNAPNHTNSSQEDAAETSVQTQSNVSSEDPDEERGVKLGLGDFIFYSVLVGKAAATASGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLIFYFSTDNIVRPFMDTLASHQMYI","proteome":"UP000008143","gene":"psen2","go_terms":[{"identifier":"GO:0042500","name":"aspartic endopeptidase activity, intramembrane cleaving","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0016485","name":"protein processing","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"c661181a01b211ed2d1c8b8b5e8a3bdf1b271f93","counters":{"domain_architectures":4227,"entries":8,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"smart":1,"cathgene3d":1,"panther":1,"pfam":1,"prints":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":4227}}}