{"metadata":{"accession":"F6ZP91","id":"F6ZP91_MACMU","source_organism":{"taxId":"9544","scientificName":"Macaca mulatta","fullName":"Macaca mulatta (Rhesus macaque)"},"name":"Sphingosine-1-phosphate transporter MFSD2B","description":["Lipid transporter that specifically mediates export of sphingosine-1-phosphate in red blood cells and platelets. Sphingosine-1-phosphate is a signaling sphingolipid and its export from red blood cells into in the plasma is required for red blood cell morphology. Sphingosine-1-phosphate export from platelets is required for platelet aggregation and thrombus formation. Mediates the export of different sphingosine-1-phosphate (S1P) species, including S1P(d18:0) (sphinganine 1-phosphate), S1P (d18:1) (sphing-4-enine 1-phosphate) and S1P (d18:2) (sphinga-4E,14Z-dienine-1-phosphate). Release of sphingosine-1-phosphate is facilitated by a proton gradient. In contrast, cations, such as sodium, are not required to drive sphingosine-1-phosphate transport. In addition to export, also able to mediate S1P import. Does not transport lysophosphatidylcholine (LPC)"],"length":504,"sequence":"MAAPPAPATEGSPQPEPHVREPGPGSARRGREDSRASRLSFCTKVCYGIGGVPNQIASSATAFYLQLFLLDIAQIPAAQVSLVLFGGKVSGAAADPVAGFFINRSQRTGSGRLMPWVLGCTPFIALAYFFLWFLPPFTSLRGLWYTTFYCLFQGLATFFQVPYTALTMLLTPCPRERDSATAYRMTVEMAGTLMGATVHGLIVSGAHKHHRCEATVTPGPVTVSPNAARLYYIAAAVVAVTYPVCSSLLCLGVKERPDPSTPASGPGLSFLAGLGLTTRHPPYLKLVISFLFISAAVQVEQSYLVLFCTHASQLHDHVQGLVLTVLVSAVLSTPLWEWVLQRFGKKMSAFGISAMVPFAILLAAVPTAPVAYVVAFVSGVSIAVSLLLPWSMLPDVVDDFQLQHHHGPGLETIFYSSYVFFTKLSGACALGISTLSLEFSGYKAGACKQAEEVVVTLKVLIGAVPTCMILAGLCILMVGSTPKTPSQDASSRLSLRRRTSYSLA","proteome":"UP000006718","gene":"MFSD2B","go_terms":[{"identifier":"GO:0015293","name":"symporter activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008643","name":"carbohydrate transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"18700fec056a4a6b8afdaf19377d37db5df6a411","counters":{"domain_architectures":42036,"entries":6,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"panther":1,"pfam":1,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":42036}}}