{"metadata":{"accession":"F6RCR5","id":"F6RCR5_MACMU","source_organism":{"taxId":"9544","scientificName":"Macaca mulatta","fullName":"Macaca mulatta (Rhesus macaque)"},"name":"Sodium/myo-inositol cotransporter 2","description":["Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Can also transport D-chiro-inositol (DCI) but not L-fucose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney"],"length":640,"sequence":"MESGTSRPQPPQTDLLDAFPQNGLEPGDIAVLVLYFLFVLAVGLWSTVKTKRDTVKGYFLAGGDMVWWPVGASLFASNVGSGHFIGLAGSGAATGLSVSAYELNGLFSVLMLAWIFLPIYIAGQVDMYAGAIFIQQSLHLDLYLAIVGLLAITAVYTVAGGLAAVIYTDALQTLIMLIGALTLMGYSFAAVGGMEGLKEKYFLALASNRSENSSCGLPREDAFHIFRDPLTSDLPWPGVLFGMSIPSLWYWCTDQVIVQRTLAAKNLSHAKGGALMAAYLKVLPLFIMVFPGMVSRILFPDQVACADPEMCRKICSNPSGCSDIAYPKLVLELLPTGLRGLMMAVMVAALMSSLTSIFNSASTIFTMDLWNHLRPRASEKELMIVGRVFVLLLVLVSILWIPVVQASQGGQLFIYIQSISSYLQPPVAVVFIMGCFWKRTNEKGAFWGLISGLLLGLIRLVLDFIYVQPRCDQPDERPVLVKSIHYLYFSMILSTVTLITVSTVSWFTESPSKEMVSHLTWFTRHDPAVQKEPATPAAPLSLALSQNGMPEASSSSRVQFEMVQENVSKTHSCDMTPKQSKVVKAILWLCGIQDKGKEELPARAEPVIVSLEENPLVKTLLDVNLIFCVTCAIFIWGYFA","proteome":"UP000006718","gene":"SLC5A11","go_terms":[{"identifier":"GO:0022857","name":"transmembrane transporter activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0055085","name":"transmembrane transport","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"947fde80f8c00410aaaf2a9849a1e19ff7e9a51e","counters":{"domain_architectures":10718,"entries":7,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"profile":1,"cathgene3d":1,"pfam":1,"ncbifam":1,"panther":1,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":10718}}}