{"metadata":{"accession":"F5P2A4","id":"F5P2A4_SHIFL","source_organism":{"taxId":"766147","scientificName":"Shigella flexneri K-227","fullName":"Shigella flexneri K-227"},"name":"Coenzyme A biosynthesis bifunctional protein CoaBC","description":["Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine","This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA"],"length":551,"sequence":"MSLAGKKIVLGISGGIAAYKTPELVRRLRDRGADVRVAMTEAAKAFITPLSLQAVSGYPVSDSLLDPAAEAAMGHIELGKWADLVILAPATADLIARVAAGMANDLVSTICLATPAPVAVLPAMNQQMYRAAATQHNLEVLASRGLLIWGPDSGSQACGDIGPGRMLDPLTIVDMAVAHFSPVNDLKHLNIMITAGPTREPLDPVRYISNHSSGKMGFAIAAAAARRGANVTLVSGPVSLPTPPFVKRVDVMTALEMEAAVNASVQQQNIFIGCAAVADYRAATVAPEKIKKQATQGDELTIKMVKNPDIVAGVAALKDHRPYVVGFAAETNNVEEYARQKRIRKNLDLICANDVSQPTQGFNSDNNALHLFWQDGDKVLPLERKELLGQLLLDEIVTRYDEKIDVKILDPRVGKEFPLPTYATSGSAGLDLRACLDDAVELAPGDTTLVPTGLAIHIADPSLAAMMLPRSGLGHKHGIVLGNLVGLIDSDYQGQLMISVWNRGQDSFTIQPGERIAQMIFVPVVQAEFNLVEDFDATDRGEGGFGHSGRQ","proteome":null,"gene":"coaBC","go_terms":[{"identifier":"GO:0003824","name":"catalytic activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004632","name":"phosphopantothenate--cysteine ligase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004633","name":"phosphopantothenoylcysteine decarboxylase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0010181","name":"FMN binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0015937","name":"coenzyme A biosynthetic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0015941","name":"pantothenate catabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0000287","name":"magnesium ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004170","name":"dUTP diphosphatase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006226","name":"dUMP biosynthetic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0046081","name":"dUTP catabolic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"e23a7eb18f808c580f1ecab0fb5c50ed9130223d","counters":{"domain_architectures":4,"entries":25,"isoforms":0,"proteomes":0,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":3,"ssf":3,"pfam":3,"cdd":1,"ncbifam":3,"panther":1,"hamap":2,"interpro":9},"proteome":0,"taxonomy":1,"similar_proteins":4}}}