{"metadata":{"accession":"F5P0V9","id":"F5P0V9_SHIFL","source_organism":{"taxId":"766147","scientificName":"Shigella flexneri K-227","fullName":"Shigella flexneri K-227"},"name":"Zinc resistance-associated protein","description":["Part of the Zra signaling pathway, an envelope stress response (ESR) system composed of the periplasmic accessory protein ZraP, the histidine kinase ZraS and the transcriptional regulator ZraR. The ZraPSR system contributes to antibiotic resistance and is important for membrane integrity in the presence of membrane-targeting biocides. ZraP acts as a modulator which has both a regulatory and a chaperone function. The zinc-bound form of ZraP modulates the response of the ZraPSR system by inhibiting the expression of the zra genes, probably by interacting with ZraS"],"length":141,"sequence":"MKRNTKIALVMMALSAMAMGSTSAFAHGGHGMWQQNAAPLTSEQQTAWQKIHNDFYAQSSALQQQLVTKRYEYNALLAANPPDSSKINAVAKEMENLRQSLDELRVKRDIAMAEAGIPRGAGMGMGYGGCGGGGHMGMGHW","proteome":null,"gene":"SFK227_4096","go_terms":null,"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"0c9ce251144a5f51149a48b1aec52fea869ab4cc","counters":{"domain_architectures":4566,"entries":4,"isoforms":0,"proteomes":0,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ncbifam":1,"pfam":1,"interpro":1},"proteome":0,"taxonomy":1,"similar_proteins":4566}}}