{"metadata":{"accession":"E1F0W7","id":"E1F0W7_GIAIA","source_organism":{"taxId":"658858","scientificName":"Giardia intestinalis (strain P15)","fullName":"Giardia intestinalis (strain P15)"},"name":"Endonuclease III homolog","description":["Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines"],"length":323,"sequence":"MAPIPDLEDTWEKIEAMRAEYVCPVDVFGAHMLSDTTETPDGRFRFAIGLLLSARNLDRVTAAAMYKLNHMLPVPPDGLDKERLKKLEAEFEENTKGLQKSTKAEAMLKKNFPIDIENLMKLNTWRLTAKNVVDSGLDELGRIIHPVGFCRRKAEYMKNVAQICLDNYGGDIPKDLAGILKLPGFGPKMGHLLVQIVYGQVEGIAVDTHVCRIAQRLRWVEKGMCEPNGKMLNPDDVAKQLVETLPKDKWRDINHLLVGFGQTVCKASFPECNRCLIAGTGRCYHKPETKPEAGAGKPRNRERRAKASRRDAEGQGGITDEDE","proteome":null,"gene":"NTH1","go_terms":[{"identifier":"GO:0003824","name":"catalytic activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006281","name":"DNA repair","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0006284","name":"base-excision repair","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003906","name":"DNA-(apurinic or apyrimidinic site) endonuclease activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0019104","name":"DNA N-glycosylase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006285","name":"base-excision repair, AP site formation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005634","name":"nucleus","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"101d5cd9986e339cda16b6cf5f3a516003f98a8c","counters":{"domain_architectures":26078,"entries":12,"isoforms":0,"proteomes":0,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"cathgene3d":2,"smart":1,"cdd":1,"pfam":1,"hamap":1,"panther":1,"interpro":4},"proteome":0,"taxonomy":1,"similar_proteins":26078}}}