{"metadata":{"accession":"D9IG03","id":"D9IG03_9MURI","source_organism":{"taxId":"69075","scientificName":"Rattus losea","fullName":"Rattus losea (lesser rice-field rat)"},"name":"LARGE-2","description":["Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity and in a phosphorylated-O-mannosyl trisaccharide dependent manner. Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide. Supports the maturation of DAG1 more effectively than LARGE1. In addition, can modify both heparan sulfate (HS)- and chondroitin/dermatan sulfate (CS/DS)-proteoglycans (PGs), namely GPC4, with a glycosaminoglycan (GAG)-like polysaccharide composed of xylose and glucuronic acid to confer laminin binding"],"length":654,"sequence":"ALQLLLLLVVFFFLVRQPPEYGRGTTPTDEGEPWGSRSCSTFIQQLLLPTKCEMLHVAIVCAGYNSSREIITLMKSVLFYRKNPLHLHLITDAVARNILETLFRTWMVPAVVVSFYDAEELKPLVSWIPNKHYSGLYGLMKLVLPSVLPLSLTRVIVLDTDVTFSSDIMELWALFGHFSDKQVVGLVENQSDWYLGNLWKNHRPWPALGRGFNTGVILLWLDRLQQIGWEQMWKLTAKRELLTLTATSLADQDIFNAVIKEHPELVHPLPCVWNVQLSDHTLAERCYLEAADLKVIHWNSPKKLRVKNKHAEFFRDLHLTFLGFDGKLLCRELFGCPNQFPPGAEQLQQALAQLDEEEPCFEFRQQQLTVHRVHITFLSHQPPPPRPHDVTLVAQLSMDRLQMLEALCRHWRGPMSLALYLTDAEAQQFLRFVETSPVLSARKDVAYHVVYRDGPLYPVNQLRNVALAQALTPYVFLSDIDFLPAYSLYDYLRASIEQLALGRRQRKAALVVPAFETLHYRFSFPNSKAELLTLLDAGSLHTFRYHEWPQGHASTDYTRWREAQAPYRVQWSADYEPYVVVPRDCPRYDPRFVGFGWNKVAHIIELDAQEYEFLVLPEAFSIHLPHAPSLDISRFRSSPTYRDCLQALKEEFHQ","proteome":null,"gene":null,"go_terms":[{"identifier":"GO:0016757","name":"glycosyltransferase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":2,"source_database":"unreviewed","is_fragment":true,"in_alphafold":true,"in_bfvd":false,"ida_accession":"bdfcf100d7a7cc1df9326a3a01ad4f94fc9bfa73","counters":{"domain_architectures":681,"entries":9,"isoforms":0,"proteomes":0,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cdd":1,"ssf":1,"cathgene3d":1,"pfam":2,"panther":1,"interpro":3},"proteome":0,"taxonomy":1,"similar_proteins":681}}}